Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound

Rong Yang, Nerandra T. Sanghvi, Frederick Rescorla, Carlos A. Galliani, Francis J. Fry, Steven L. Griffith, Jay L. Grosfeld

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Rationale and Objectives: High-intensity focused ultrasound (HIFU) is the only radiation beam that can remotely destroy deep-seated tissue targets without causing damage to the intervening tissues. This study evaluates the ability of sonography- guided HIFU to extracorporeally induce liver ablation in a rabbit model. METHODS Under sonographic guidance, the HIFU beam was transcutaneously focused at the target tissue in the liver through a subcostal approach. A computer controlled the HIFU exposure and transducer movement to destroy a preselected tissue volume. Simultaneous sonography monitored the tissue response. Ten insonated rabbits were killed from days 0 to 10, and the liver and intervening tissues were examined histologically. Results: A sharply demarcated sonolesion of coagulation necrosis was produced in the liver in 9 of 10 animals. No damage was found in the intervening tissues (n = 6) when adequate acoustic coupling and proper beam path was applied. Conclusion: Sonography-guided HIFU might be a potential new modality for extracorporeal inducement of liver cancer ablation without resorting to laparatomy.

Original languageEnglish
Pages (from-to)796-803
Number of pages8
JournalInvestigative Radiology
Volume27
Issue number10
StatePublished - 1992
Externally publishedYes

Fingerprint

Ultrasonography
Liver
Rabbits
Liver Neoplasms
Transducers
Acoustics
Necrosis
Radiation

Keywords

  • High-intensity focused ultrasound
  • Liver ablation
  • Liver cancer
  • Noninvasive therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Yang, R., Sanghvi, N. T., Rescorla, F., Galliani, C. A., Fry, F. J., Griffith, S. L., & Grosfeld, J. L. (1992). Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound. Investigative Radiology, 27(10), 796-803.

Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound. / Yang, Rong; Sanghvi, Nerandra T.; Rescorla, Frederick; Galliani, Carlos A.; Fry, Francis J.; Griffith, Steven L.; Grosfeld, Jay L.

In: Investigative Radiology, Vol. 27, No. 10, 1992, p. 796-803.

Research output: Contribution to journalArticle

Yang, R, Sanghvi, NT, Rescorla, F, Galliani, CA, Fry, FJ, Griffith, SL & Grosfeld, JL 1992, 'Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound', Investigative Radiology, vol. 27, no. 10, pp. 796-803.
Yang R, Sanghvi NT, Rescorla F, Galliani CA, Fry FJ, Griffith SL et al. Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound. Investigative Radiology. 1992;27(10):796-803.
Yang, Rong ; Sanghvi, Nerandra T. ; Rescorla, Frederick ; Galliani, Carlos A. ; Fry, Francis J. ; Griffith, Steven L. ; Grosfeld, Jay L. / Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound. In: Investigative Radiology. 1992 ; Vol. 27, No. 10. pp. 796-803.
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