Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound

Rong Yang, Nerandra T. Sanghvi, Frederick J. Rescorla, Carlos A. Galliani, Francis J. Fry, Steven L. Griffith, Jay L. Grosfeld

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Rationale and Objectives: High-intensity focused ultrasound (HIFU) is the only radiation beam that can remotely destroy deep-seated tissue targets without causing damage to the intervening tissues. This study evaluates the ability of sonography- guided HIFU to extracorporeally induce liver ablation in a rabbit model. METHODS Under sonographic guidance, the HIFU beam was transcutaneously focused at the target tissue in the liver through a subcostal approach. A computer controlled the HIFU exposure and transducer movement to destroy a preselected tissue volume. Simultaneous sonography monitored the tissue response. Ten insonated rabbits were killed from days 0 to 10, and the liver and intervening tissues were examined histologically. Results: A sharply demarcated sonolesion of coagulation necrosis was produced in the liver in 9 of 10 animals. No damage was found in the intervening tissues (n = 6) when adequate acoustic coupling and proper beam path was applied. Conclusion: Sonography-guided HIFU might be a potential new modality for extracorporeal inducement of liver cancer ablation without resorting to laparatomy.

Original languageEnglish (US)
Pages (from-to)796-803
Number of pages8
JournalInvestigative Radiology
Volume27
Issue number10
DOIs
StatePublished - Oct 1992
Externally publishedYes

Keywords

  • High-intensity focused ultrasound
  • Liver ablation
  • Liver cancer
  • Noninvasive therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Yang, R., Sanghvi, N. T., Rescorla, F. J., Galliani, C. A., Fry, F. J., Griffith, S. L., & Grosfeld, J. L. (1992). Extracorporeal liver ablation using sonography-guided high-intensity focused ultrasound. Investigative Radiology, 27(10), 796-803. https://doi.org/10.1097/00004424-199210000-00009