Extracorporeal shock wave lithotripsy at 60 shock waves/min reduces renal injury in a porcine model

Bret A. Connors, Andrew P. Evan, Philip M. Blomgren, Rajash K. Handa, Lynn R. Willis, Sujuan Gao, James A. McAteer, James E. Lingeman

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective: To determine if extracorporeal shock wave lithotripsy (ESWL) at 60 shock waves (SWs)/min reduces renal damage and haemodynamic impairment compared to treatment at 120 SWs/min. MATERIALS AND METHODS One kidney in each of 19 juvenile pigs (7-8 weeks old) was treated at 120 or at 60 SWs/min (2000 SWs, 24 kV) with an unmodified HM-3 lithotripter (Dornier Medical Systems, Kennesaw, GA, USA). Renal function was determined before and after ESWL treatment by inulin clearance, extraction and clearance of para-aminohippuric acid. Both kidneys were then removed to measure parenchymal lesion size by sectioning the entire kidney and quantifying the size of the haemorrhagic lesion in each slice. Results: ESWL at 60 SWs/min significantly reduced the size of the acute morphological lesion compared to 120 SWs/min (0.42% vs 3.93% of functional renal volume, P = 0.011) and blunted the decrease in glomerular filtration rate and renal plasma flow normally seen after treatment at 120 SWs/min. Conclusions: Treatment at a firing rate of 60 SWs/min produces less morphological injury and causes less alteration in renal haemodynamics than treatment at 120 SWs/min in the pig model of ESWL-induced renal injury.

Original languageEnglish (US)
Pages (from-to)1004-1008
Number of pages5
JournalBJU International
Volume104
Issue number7
DOIs
StatePublished - Oct 2009

Keywords

  • Extracorporeal shock wave lithotripsy
  • Pig model
  • Renal lesion size

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

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