Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population

Ralph E. Hoffman, Scott W. Woods, Keith A. Hawkins, Brian Pittman, Mauricio Tohen, Adrian Preda, Alan Breier, Jill Glist, Jean Addington, Diana O. Perkins, Thomas H. McGlashan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A tendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to shizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year I followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

Original languageEnglish (US)
Pages (from-to)355-356
Number of pages2
JournalBritish Journal of Psychiatry
Volume191
Issue numberOCT.
DOIs
StatePublished - Oct 2007

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olanzapine
Noise
Schizophrenia
Population
Prodromal Symptoms
Conversion Disorder
Placebos
Regression Analysis
Pharmacology
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Hoffman, R. E., Woods, S. W., Hawkins, K. A., Pittman, B., Tohen, M., Preda, A., ... McGlashan, T. H. (2007). Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. British Journal of Psychiatry, 191(OCT.), 355-356. https://doi.org/10.1192/bjp.bp.106.031195

Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. / Hoffman, Ralph E.; Woods, Scott W.; Hawkins, Keith A.; Pittman, Brian; Tohen, Mauricio; Preda, Adrian; Breier, Alan; Glist, Jill; Addington, Jean; Perkins, Diana O.; McGlashan, Thomas H.

In: British Journal of Psychiatry, Vol. 191, No. OCT., 10.2007, p. 355-356.

Research output: Contribution to journalArticle

Hoffman, RE, Woods, SW, Hawkins, KA, Pittman, B, Tohen, M, Preda, A, Breier, A, Glist, J, Addington, J, Perkins, DO & McGlashan, TH 2007, 'Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population', British Journal of Psychiatry, vol. 191, no. OCT., pp. 355-356. https://doi.org/10.1192/bjp.bp.106.031195
Hoffman, Ralph E. ; Woods, Scott W. ; Hawkins, Keith A. ; Pittman, Brian ; Tohen, Mauricio ; Preda, Adrian ; Breier, Alan ; Glist, Jill ; Addington, Jean ; Perkins, Diana O. ; McGlashan, Thomas H. / Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. In: British Journal of Psychiatry. 2007 ; Vol. 191, No. OCT. pp. 355-356.
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