Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population

Ralph E. Hoffman, Scott W. Woods, Keith A. Hawkins, Brian Pittman, Mauricio Tohen, Adrian Preda, Alan Breier, Jill Glist, Jean Addington, Diana O. Perkins, Thomas H. McGlashan

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43 Scopus citations

Abstract

A tendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to shizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year I followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

Original languageEnglish (US)
Pages (from-to)355-356
Number of pages2
JournalBritish Journal of Psychiatry
Volume191
Issue numberOCT.
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Hoffman, R. E., Woods, S. W., Hawkins, K. A., Pittman, B., Tohen, M., Preda, A., Breier, A., Glist, J., Addington, J., Perkins, D. O., & McGlashan, T. H. (2007). Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. British Journal of Psychiatry, 191(OCT.), 355-356. https://doi.org/10.1192/bjp.bp.106.031195