Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer

a Systematic Review and Meta-analysis

Nicola Veronese, Matteo Fassan, Laura D. Wood, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Alessia Nottegar, Giuseppe Sergi, Enzo Manzato, Sara Carraro, Marco Maruzzo, Ivana Cataldo, Fabio Bagante, Mattia Barbareschi, Liang Cheng, Maria Bencivenga, Giovanni de Manzoni, Claudio Luchini

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Introduction: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. Material and Methods: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients’ prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE−). The data were summarized using risk ratios (RRs) for the number of deaths/recurrences and hazard ratios (HRs) with 95 % confidence intervals (CI), adjusted for potential confounders. Results: Nine studies followed up 3250 patients with gastric cancer (1064 ENE+ and 2186 ENE−). ENE+ was associated with a significantly higher risk of all-cause mortality (RR = 1.70; 95 % CI: 1.43–2.03, I2 = 66 %; HR = 2.14; 95 % CI: 1.66–2.75, I2 = 0 %), cancer-specific mortality (RR = 1.59; 95 % CI: 1.42–1.79; HR = 1.52; 95 % CI: 1.19–1.96), and disease recurrence (RR = 3.43, 95 % CI: 1.80–6.54, I2 = 0 %). Discussion: Judging from our results, ENE in gastric cancer patients should be considered for prognostic purposes from the gross sample to the pathology report.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Gastrointestinal Surgery
DOIs
StateAccepted/In press - Jul 13 2016

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Stomach Neoplasms
Meta-Analysis
Confidence Intervals
Neoplasm Metastasis
Odds Ratio
Recurrence
Mortality
Capsules
Neoplasms
Databases
Pathology

Keywords

  • ENE
  • Extranodal extension
  • Gastric cancer
  • Lymph node metastasis

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Gastroenterology

Cite this

Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer : a Systematic Review and Meta-analysis. / Veronese, Nicola; Fassan, Matteo; Wood, Laura D.; Stubbs, Brendon; Solmi, Marco; Capelli, Paola; Pea, Antonio; Nottegar, Alessia; Sergi, Giuseppe; Manzato, Enzo; Carraro, Sara; Maruzzo, Marco; Cataldo, Ivana; Bagante, Fabio; Barbareschi, Mattia; Cheng, Liang; Bencivenga, Maria; de Manzoni, Giovanni; Luchini, Claudio.

In: Journal of Gastrointestinal Surgery, 13.07.2016, p. 1-7.

Research output: Contribution to journalArticle

Veronese, N, Fassan, M, Wood, LD, Stubbs, B, Solmi, M, Capelli, P, Pea, A, Nottegar, A, Sergi, G, Manzato, E, Carraro, S, Maruzzo, M, Cataldo, I, Bagante, F, Barbareschi, M, Cheng, L, Bencivenga, M, de Manzoni, G & Luchini, C 2016, 'Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer: a Systematic Review and Meta-analysis', Journal of Gastrointestinal Surgery, pp. 1-7. https://doi.org/10.1007/s11605-016-3199-7
Veronese, Nicola ; Fassan, Matteo ; Wood, Laura D. ; Stubbs, Brendon ; Solmi, Marco ; Capelli, Paola ; Pea, Antonio ; Nottegar, Alessia ; Sergi, Giuseppe ; Manzato, Enzo ; Carraro, Sara ; Maruzzo, Marco ; Cataldo, Ivana ; Bagante, Fabio ; Barbareschi, Mattia ; Cheng, Liang ; Bencivenga, Maria ; de Manzoni, Giovanni ; Luchini, Claudio. / Extranodal Extension of Nodal Metastases Is a Poor Prognostic Indicator in Gastric Cancer : a Systematic Review and Meta-analysis. In: Journal of Gastrointestinal Surgery. 2016 ; pp. 1-7.
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abstract = "Introduction: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. Material and Methods: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients’ prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE−). The data were summarized using risk ratios (RRs) for the number of deaths/recurrences and hazard ratios (HRs) with 95 {\%} confidence intervals (CI), adjusted for potential confounders. Results: Nine studies followed up 3250 patients with gastric cancer (1064 ENE+ and 2186 ENE−). ENE+ was associated with a significantly higher risk of all-cause mortality (RR = 1.70; 95 {\%} CI: 1.43–2.03, I2 = 66 {\%}; HR = 2.14; 95 {\%} CI: 1.66–2.75, I2 = 0 {\%}), cancer-specific mortality (RR = 1.59; 95 {\%} CI: 1.42–1.79; HR = 1.52; 95 {\%} CI: 1.19–1.96), and disease recurrence (RR = 3.43, 95 {\%} CI: 1.80–6.54, I2 = 0 {\%}). Discussion: Judging from our results, ENE in gastric cancer patients should be considered for prognostic purposes from the gross sample to the pathology report.",
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T2 - a Systematic Review and Meta-analysis

AU - Veronese, Nicola

AU - Fassan, Matteo

AU - Wood, Laura D.

AU - Stubbs, Brendon

AU - Solmi, Marco

AU - Capelli, Paola

AU - Pea, Antonio

AU - Nottegar, Alessia

AU - Sergi, Giuseppe

AU - Manzato, Enzo

AU - Carraro, Sara

AU - Maruzzo, Marco

AU - Cataldo, Ivana

AU - Bagante, Fabio

AU - Barbareschi, Mattia

AU - Cheng, Liang

AU - Bencivenga, Maria

AU - de Manzoni, Giovanni

AU - Luchini, Claudio

PY - 2016/7/13

Y1 - 2016/7/13

N2 - Introduction: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. Material and Methods: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients’ prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE−). The data were summarized using risk ratios (RRs) for the number of deaths/recurrences and hazard ratios (HRs) with 95 % confidence intervals (CI), adjusted for potential confounders. Results: Nine studies followed up 3250 patients with gastric cancer (1064 ENE+ and 2186 ENE−). ENE+ was associated with a significantly higher risk of all-cause mortality (RR = 1.70; 95 % CI: 1.43–2.03, I2 = 66 %; HR = 2.14; 95 % CI: 1.66–2.75, I2 = 0 %), cancer-specific mortality (RR = 1.59; 95 % CI: 1.42–1.79; HR = 1.52; 95 % CI: 1.19–1.96), and disease recurrence (RR = 3.43, 95 % CI: 1.80–6.54, I2 = 0 %). Discussion: Judging from our results, ENE in gastric cancer patients should be considered for prognostic purposes from the gross sample to the pathology report.

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KW - Lymph node metastasis

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