Extratemporal resection for childhood epilepsy

D. Barry Sinclair, Keith Aronyk, Thomas Snyder, John D.S. McKean, Matt Wheatley, Donald Gross, Alexander Bastos, S. Nizamuddin Ahmed, Chunhai Hao, William Colmers

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

There have been relatively few studies reporting the safety, efficacy, and outcome in children undergoing extratemporal resection for epilepsy. We reviewed the pediatric cases of extratemporal resection for intractable epilepsy performed by the Comprehensive Epilepsy Program at the University of Alberta Hospitals between 1988-1998. Thirty-five patients were studied, 14 male and 21 female. The age at operation ranged from 6 months to 16 years. The operations included frontal excisions (12), parietal (8), occipital (4), hemispherectomies or multilobar resections (10), and one removal of a hypothalamic hamartoma. The pathology at surgery included patients with focal cortical dysplasia (8), brain tumors (6), neurocutaneous syndrome (7), Rasmussen's encephalitis (2), porencephalic cysts (4), hypothalamic hamartoma (1), and nonspecific gliosis (6). Twenty-four of 35 patients (68.5%) had an Engel Class I outcome after surgery and an additional six patients (11%) had a significant decrease in seizure frequency (Engel Class III). Complications were observed in two patients (5%) and there were no deaths. Extratemporal resection is a safe and effective treatment for children with intractable epilepsy. Overall, 68% of patients were seizure-free after surgery, although outcome may be dependent on site and pathology. A wide range of developmental pathology was observed including focal cortical dysplasia, brain tumors, and lesions with neurocutaneous syndromes. Many families reported improvement in behavior and psychosocial function after surgery.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
JournalPediatric Neurology
Volume30
Issue number3
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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Epilepsy
Neurocutaneous Syndromes
Malformations of Cortical Development
Pathology
Brain Neoplasms
Seizures
Hemispherectomy
Alberta
Gliosis
Encephalitis
Cysts
Pediatrics
Safety
Drug Resistant Epilepsy
Hypothalamic hamartomas
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Sinclair, D. B., Aronyk, K., Snyder, T., McKean, J. D. S., Wheatley, M., Gross, D., ... Colmers, W. (2004). Extratemporal resection for childhood epilepsy. Pediatric Neurology, 30(3), 177-185. https://doi.org/10.1016/j.pediatrneurol.2003.07.005

Extratemporal resection for childhood epilepsy. / Sinclair, D. Barry; Aronyk, Keith; Snyder, Thomas; McKean, John D.S.; Wheatley, Matt; Gross, Donald; Bastos, Alexander; Ahmed, S. Nizamuddin; Hao, Chunhai; Colmers, William.

In: Pediatric Neurology, Vol. 30, No. 3, 01.01.2004, p. 177-185.

Research output: Contribution to journalArticle

Sinclair, DB, Aronyk, K, Snyder, T, McKean, JDS, Wheatley, M, Gross, D, Bastos, A, Ahmed, SN, Hao, C & Colmers, W 2004, 'Extratemporal resection for childhood epilepsy', Pediatric Neurology, vol. 30, no. 3, pp. 177-185. https://doi.org/10.1016/j.pediatrneurol.2003.07.005
Sinclair DB, Aronyk K, Snyder T, McKean JDS, Wheatley M, Gross D et al. Extratemporal resection for childhood epilepsy. Pediatric Neurology. 2004 Jan 1;30(3):177-185. https://doi.org/10.1016/j.pediatrneurol.2003.07.005
Sinclair, D. Barry ; Aronyk, Keith ; Snyder, Thomas ; McKean, John D.S. ; Wheatley, Matt ; Gross, Donald ; Bastos, Alexander ; Ahmed, S. Nizamuddin ; Hao, Chunhai ; Colmers, William. / Extratemporal resection for childhood epilepsy. In: Pediatric Neurology. 2004 ; Vol. 30, No. 3. pp. 177-185.
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