Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network

Research output: Contribution to journalArticle

Abstract

Objective: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation. Study design: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors. Results: Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity. Conclusions: One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants. Trial registration: ClinicalTrials.gov: NCT00063063 and NCT0000.

Original languageEnglish (US)
Pages (from-to)132-139.e3
JournalJournal of Pediatrics
Volume200
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Fingerprint

Extremely Premature Infants
Premature Infants
Neuroimaging
Obesity
Weight Gain
Body Mass Index
Abdominal Obesity
Waist Circumference
Fats
Hypertension

Keywords

  • hypertension
  • obese
  • overweight
  • preterm
  • school age
  • sedentary activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. / Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network.

In: Journal of Pediatrics, Vol. 200, 01.09.2018, p. 132-139.e3.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network 2018, 'Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort', Journal of Pediatrics, vol. 200, pp. 132-139.e3. https://doi.org/10.1016/j.jpeds.2018.04.073
Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network. Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. Journal of Pediatrics. 2018 Sep 1;200:132-139.e3. https://doi.org/10.1016/j.jpeds.2018.04.073
Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network. / Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. In: Journal of Pediatrics. 2018 ; Vol. 200. pp. 132-139.e3.
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T1 - Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

AU - Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network

AU - Vohr, Betty R.

AU - Heyne, Roy

AU - Bann, Carla M.

AU - Das, Abhik

AU - Higgins, Rosemary D.

AU - Hintz, Susan R.

AU - Jobe, Alan H.

AU - Caplan, Michael S.

AU - Polin, Richard A.

AU - Laptook, Abbot R.

AU - Hensman, Angelita M.

AU - McGowan, Elisabeth C.

AU - Vieira, Elisa

AU - Little, Emilee

AU - Johnson, Katharine

AU - Alksninis, Barbara

AU - Keszler, Mary Lenore

AU - Knoll, Andrea M.

AU - Leach, Theresa M.

AU - Watson, Victoria E.

AU - Walsh, Michele C.

AU - Fanaroff, Avroy A.

AU - Wilson-Costello, Deanne E.

AU - Payne, Allison

AU - Newman, Nancy S.

AU - Taylor, H. Gerry

AU - Siner, Bonnie S.

AU - Zadell, Arlene

AU - DiFiore, Julie

AU - Bhola, Monika

AU - Friedman, Harriet G.

AU - Yalcinkaya, Gulgun

AU - Bulas, Dorothy

AU - Goldberg, Ronald N.

AU - Cotten, C. Michael

AU - Goldstein, Ricki F.

AU - Gustafson, Kathryn E.

AU - Ashley, Patricia

AU - Auten, Kathy J.

AU - Fisher, Kimberley A.

AU - Foy, Katherine A.

AU - Freedman, Sharon F.

AU - Lohmeyer, Melody B.

AU - Malcolm, William F.

AU - Wallace, David K.

AU - Carlton, David P.

AU - Stoll, Barbara J.

AU - Adams-Chapman, Ira

AU - Buchter, Susie

AU - Piazza, Anthony J.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation. Study design: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors. Results: Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity. Conclusions: One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants. Trial registration: ClinicalTrials.gov: NCT00063063 and NCT0000.

AB - Objective: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation. Study design: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors. Results: Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity. Conclusions: One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants. Trial registration: ClinicalTrials.gov: NCT00063063 and NCT0000.

KW - hypertension

KW - obese

KW - overweight

KW - preterm

KW - school age

KW - sedentary activity

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