Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma

Erin X. Wei, Xin Li, Hongmei Nan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The presence of nevi portends an increased risk for melanoma. Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers. Methods: We evaluated prospective cohorts of 176,317 women (the Nurses’ Health Study, 1986-2012 and the Nurses’ Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Information on nevus count (none, 1-5, 6-14, ≥15) on the extremity was collected at baseline. Results: There were 1704 incident cases of melanoma, 2296 incident cases of squamous cell carcinoma, and 30,457 incident cases of basal cell carcinoma, with a total of 4,655,043 person-years for melanoma and 4,267,708 person-years for keratinocyte cancers. The presence of an extremity nevus was associated with an increased risk of melanoma in all anatomic areas and increased risk of basal cell carcinoma (BCC). Individuals with ≥15 nevi had the highest risk of melanoma and BCC compared to those without any extremity nevi (melanoma hazard ratio 2.79 [95% confidence interval 2.04-3.83]; BCC HR 1.40 [95% confidence interval 1.32-1.49]). No significant association was observed for squamous cell carcinoma. Limitations: Limitations of our study included self-reported nevus count and detection bias. Conclusions: Extremity nevus count is a helpful clinical marker in risk-stratifying individuals for BCC and melanoma on all body sites.

Original languageEnglish (US)
JournalJournal of the American Academy of Dermatology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Nevus
Basal Cell Carcinoma
Squamous Cell Carcinoma
Melanoma
Extremities
Keratinocytes
Nurses
Confidence Intervals
Nevi and Melanomas
Men's Health
Women's Health
Neoplasms
Biomarkers
Health

Keywords

  • basal cell carcinoma
  • melanoma
  • nevus count
  • prospective cohort studies
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{5391214ba73e4eb79ec6b14995282902,
title = "Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma",
abstract = "Background: The presence of nevi portends an increased risk for melanoma. Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers. Methods: We evaluated prospective cohorts of 176,317 women (the Nurses’ Health Study, 1986-2012 and the Nurses’ Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Information on nevus count (none, 1-5, 6-14, ≥15) on the extremity was collected at baseline. Results: There were 1704 incident cases of melanoma, 2296 incident cases of squamous cell carcinoma, and 30,457 incident cases of basal cell carcinoma, with a total of 4,655,043 person-years for melanoma and 4,267,708 person-years for keratinocyte cancers. The presence of an extremity nevus was associated with an increased risk of melanoma in all anatomic areas and increased risk of basal cell carcinoma (BCC). Individuals with ≥15 nevi had the highest risk of melanoma and BCC compared to those without any extremity nevi (melanoma hazard ratio 2.79 [95{\%} confidence interval 2.04-3.83]; BCC HR 1.40 [95{\%} confidence interval 1.32-1.49]). No significant association was observed for squamous cell carcinoma. Limitations: Limitations of our study included self-reported nevus count and detection bias. Conclusions: Extremity nevus count is a helpful clinical marker in risk-stratifying individuals for BCC and melanoma on all body sites.",
keywords = "basal cell carcinoma, melanoma, nevus count, prospective cohort studies, squamous cell carcinoma",
author = "Wei, {Erin X.} and Xin Li and Hongmei Nan",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jaad.2018.09.044",
language = "English (US)",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
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}

TY - JOUR

T1 - Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma

AU - Wei, Erin X.

AU - Li, Xin

AU - Nan, Hongmei

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The presence of nevi portends an increased risk for melanoma. Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers. Methods: We evaluated prospective cohorts of 176,317 women (the Nurses’ Health Study, 1986-2012 and the Nurses’ Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Information on nevus count (none, 1-5, 6-14, ≥15) on the extremity was collected at baseline. Results: There were 1704 incident cases of melanoma, 2296 incident cases of squamous cell carcinoma, and 30,457 incident cases of basal cell carcinoma, with a total of 4,655,043 person-years for melanoma and 4,267,708 person-years for keratinocyte cancers. The presence of an extremity nevus was associated with an increased risk of melanoma in all anatomic areas and increased risk of basal cell carcinoma (BCC). Individuals with ≥15 nevi had the highest risk of melanoma and BCC compared to those without any extremity nevi (melanoma hazard ratio 2.79 [95% confidence interval 2.04-3.83]; BCC HR 1.40 [95% confidence interval 1.32-1.49]). No significant association was observed for squamous cell carcinoma. Limitations: Limitations of our study included self-reported nevus count and detection bias. Conclusions: Extremity nevus count is a helpful clinical marker in risk-stratifying individuals for BCC and melanoma on all body sites.

AB - Background: The presence of nevi portends an increased risk for melanoma. Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers. Methods: We evaluated prospective cohorts of 176,317 women (the Nurses’ Health Study, 1986-2012 and the Nurses’ Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Information on nevus count (none, 1-5, 6-14, ≥15) on the extremity was collected at baseline. Results: There were 1704 incident cases of melanoma, 2296 incident cases of squamous cell carcinoma, and 30,457 incident cases of basal cell carcinoma, with a total of 4,655,043 person-years for melanoma and 4,267,708 person-years for keratinocyte cancers. The presence of an extremity nevus was associated with an increased risk of melanoma in all anatomic areas and increased risk of basal cell carcinoma (BCC). Individuals with ≥15 nevi had the highest risk of melanoma and BCC compared to those without any extremity nevi (melanoma hazard ratio 2.79 [95% confidence interval 2.04-3.83]; BCC HR 1.40 [95% confidence interval 1.32-1.49]). No significant association was observed for squamous cell carcinoma. Limitations: Limitations of our study included self-reported nevus count and detection bias. Conclusions: Extremity nevus count is a helpful clinical marker in risk-stratifying individuals for BCC and melanoma on all body sites.

KW - basal cell carcinoma

KW - melanoma

KW - nevus count

KW - prospective cohort studies

KW - squamous cell carcinoma

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