Eye-tracking, attention and amphetamine challenge

Larry J. Siever, Thomas R. Insel, Jean Hamilton, John Nurnberger, Ina Alterman, Dennis L. Murphy

Research output: Contribution to journalArticle

10 Scopus citations


Smooth pursuit eye movement (SPEM) performance has been linked to nonvoluntary attentional processes. Amphetamine is a psychotropic drug with documented effects on attentional performance. In order to evaluate the relationship between SPEM performance and amphetamine's attentional effects, SPEM performance was measured prior to and following amphetamine administration in five bipolar patients and eight obsessive-compulsive patients. In these 13 patients, amphetamine did not significantly alter the accuracy of SPEM in the two patient groups. However, significant negative correlations were observed in the obsessive-compulsive patients and in the combined patient groups between baseline SPEM impairment and changes in eye-tracking accuracy following amphetamine, i.e. individuals with poorer SPEM accuracy improved while better SPEM performers deteriorated in tracking accuracy during amphetamine treatment.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalJournal of Psychiatric Research
Issue number2
StatePublished - 1987
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Siever, L. J., Insel, T. R., Hamilton, J., Nurnberger, J., Alterman, I., & Murphy, D. L. (1987). Eye-tracking, attention and amphetamine challenge. Journal of Psychiatric Research, 21(2), 129-135. https://doi.org/10.1016/0022-3956(87)90013-6