Eyeblink conditioning anomalies in bipolar disorder suggest cerebellar dysfunction

Amanda R. Bolbecker, Crystal Mehta, Jason K. Johannesen, Chad R. Edwards, Brian O'Donnell, Anantha Shekhar, John Nurnberger, Joseph E. Steinmetz, William P. Hetrick

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: Accumulating research implicates the cerebellum in non-motor psychological processes and psychiatric diseases, including bipolar disorder (BD). Despite recent evidence that cerebellar lesions have been documented to trigger bipolar-like symptoms, few studies have directly examined the functional integrity of the cerebellum in those afflicted with BD. Methods: Using a single-cue delay eyeblink conditioning procedure, the functional integrity of the cerebellum was examined in 28 individuals with BD (9 manic, 8 mixed, and 11 euthymic) and 28 age-matched healthy controls. Results: Analysis of the bipolar group as a whole indicated a conditioned response acquisition and timing deficit compared to controls. However, when the bipolar group was categorized according to mood state (mixed, manic, euthymic), individuals tested during mixed episodes were strikingly impaired, performing significantly worse than all other groups on both the acquisition and timing of conditioned responses. Conclusions: These findings extend prior research implicating cerebellar functional abnormalities in BD and suggest that cerebellar dysfunction may be associated with mood state and course of illness.

Original languageEnglish
Pages (from-to)19-32
Number of pages14
JournalBipolar Disorders
Volume11
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Cerebellar Diseases
Bipolar Disorder
Cerebellum
Research
Cues
Psychiatry
Conditioning (Psychology)
Psychology

Keywords

  • Bipolar disorder
  • Cerebellum
  • Depression
  • Eyeblink conditioning
  • Mania mixed
  • Temporal
  • Timing

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Eyeblink conditioning anomalies in bipolar disorder suggest cerebellar dysfunction. / Bolbecker, Amanda R.; Mehta, Crystal; Johannesen, Jason K.; Edwards, Chad R.; O'Donnell, Brian; Shekhar, Anantha; Nurnberger, John; Steinmetz, Joseph E.; Hetrick, William P.

In: Bipolar Disorders, Vol. 11, No. 1, 2009, p. 19-32.

Research output: Contribution to journalArticle

Bolbecker, Amanda R. ; Mehta, Crystal ; Johannesen, Jason K. ; Edwards, Chad R. ; O'Donnell, Brian ; Shekhar, Anantha ; Nurnberger, John ; Steinmetz, Joseph E. ; Hetrick, William P. / Eyeblink conditioning anomalies in bipolar disorder suggest cerebellar dysfunction. In: Bipolar Disorders. 2009 ; Vol. 11, No. 1. pp. 19-32.
@article{ab5b4de8b2084c0f8fb835f37c84c5f7,
title = "Eyeblink conditioning anomalies in bipolar disorder suggest cerebellar dysfunction",
abstract = "Objectives: Accumulating research implicates the cerebellum in non-motor psychological processes and psychiatric diseases, including bipolar disorder (BD). Despite recent evidence that cerebellar lesions have been documented to trigger bipolar-like symptoms, few studies have directly examined the functional integrity of the cerebellum in those afflicted with BD. Methods: Using a single-cue delay eyeblink conditioning procedure, the functional integrity of the cerebellum was examined in 28 individuals with BD (9 manic, 8 mixed, and 11 euthymic) and 28 age-matched healthy controls. Results: Analysis of the bipolar group as a whole indicated a conditioned response acquisition and timing deficit compared to controls. However, when the bipolar group was categorized according to mood state (mixed, manic, euthymic), individuals tested during mixed episodes were strikingly impaired, performing significantly worse than all other groups on both the acquisition and timing of conditioned responses. Conclusions: These findings extend prior research implicating cerebellar functional abnormalities in BD and suggest that cerebellar dysfunction may be associated with mood state and course of illness.",
keywords = "Bipolar disorder, Cerebellum, Depression, Eyeblink conditioning, Mania mixed, Temporal, Timing",
author = "Bolbecker, {Amanda R.} and Crystal Mehta and Johannesen, {Jason K.} and Edwards, {Chad R.} and Brian O'Donnell and Anantha Shekhar and John Nurnberger and Steinmetz, {Joseph E.} and Hetrick, {William P.}",
year = "2009",
doi = "10.1111/j.1399-5618.2008.00642.x",
language = "English",
volume = "11",
pages = "19--32",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "1",

}

TY - JOUR

T1 - Eyeblink conditioning anomalies in bipolar disorder suggest cerebellar dysfunction

AU - Bolbecker, Amanda R.

AU - Mehta, Crystal

AU - Johannesen, Jason K.

AU - Edwards, Chad R.

AU - O'Donnell, Brian

AU - Shekhar, Anantha

AU - Nurnberger, John

AU - Steinmetz, Joseph E.

AU - Hetrick, William P.

PY - 2009

Y1 - 2009

N2 - Objectives: Accumulating research implicates the cerebellum in non-motor psychological processes and psychiatric diseases, including bipolar disorder (BD). Despite recent evidence that cerebellar lesions have been documented to trigger bipolar-like symptoms, few studies have directly examined the functional integrity of the cerebellum in those afflicted with BD. Methods: Using a single-cue delay eyeblink conditioning procedure, the functional integrity of the cerebellum was examined in 28 individuals with BD (9 manic, 8 mixed, and 11 euthymic) and 28 age-matched healthy controls. Results: Analysis of the bipolar group as a whole indicated a conditioned response acquisition and timing deficit compared to controls. However, when the bipolar group was categorized according to mood state (mixed, manic, euthymic), individuals tested during mixed episodes were strikingly impaired, performing significantly worse than all other groups on both the acquisition and timing of conditioned responses. Conclusions: These findings extend prior research implicating cerebellar functional abnormalities in BD and suggest that cerebellar dysfunction may be associated with mood state and course of illness.

AB - Objectives: Accumulating research implicates the cerebellum in non-motor psychological processes and psychiatric diseases, including bipolar disorder (BD). Despite recent evidence that cerebellar lesions have been documented to trigger bipolar-like symptoms, few studies have directly examined the functional integrity of the cerebellum in those afflicted with BD. Methods: Using a single-cue delay eyeblink conditioning procedure, the functional integrity of the cerebellum was examined in 28 individuals with BD (9 manic, 8 mixed, and 11 euthymic) and 28 age-matched healthy controls. Results: Analysis of the bipolar group as a whole indicated a conditioned response acquisition and timing deficit compared to controls. However, when the bipolar group was categorized according to mood state (mixed, manic, euthymic), individuals tested during mixed episodes were strikingly impaired, performing significantly worse than all other groups on both the acquisition and timing of conditioned responses. Conclusions: These findings extend prior research implicating cerebellar functional abnormalities in BD and suggest that cerebellar dysfunction may be associated with mood state and course of illness.

KW - Bipolar disorder

KW - Cerebellum

KW - Depression

KW - Eyeblink conditioning

KW - Mania mixed

KW - Temporal

KW - Timing

UR - http://www.scopus.com/inward/record.url?scp=58149495119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149495119&partnerID=8YFLogxK

U2 - 10.1111/j.1399-5618.2008.00642.x

DO - 10.1111/j.1399-5618.2008.00642.x

M3 - Article

VL - 11

SP - 19

EP - 32

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 1

ER -