Eyeblink conditioning deficits indicate timing and cerebellar abnormalities in schizophrenia

S. M. Brown, P. D. Kieffaber, C. A. Carroll, J. L. Vohs, J. A. Tracy, A. Shekhar, B. F. O'Donnell, J. E. Steinmetz, W. P. Hetrick

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Accumulating evidence indicates that individuals with schizophrenia manifest abnormalities in structures (cerebellum and basal ganglia) and neurotransmitter systems (dopamine) linked to internal-timing processes. A single-cue tone delay eyeblink conditioning paradigm comprised of 100 learning and 50 extinction trials was used to examine cerebellar timing circuits in 13 medicated patients with schizophrenia and 13 age- and sex-matched controls. Patients with schizophrenia showed impaired learning of the conditioned response compared to controls and also greater within-subject variability in the timing of their responses. These findings are consistent with models of schizophrenia in which timing deficits underlie information-processing abnormalities and clinical features of the disorder.

Original languageEnglish (US)
Pages (from-to)94-108
Number of pages15
JournalBrain and Cognition
Volume58
Issue number1
DOIs
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

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