Facile fully automated radiosynthesis and quality control of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) for human brain tumor imaging

Min Wang, Barbara E. Glick-Wilson, Qi-Huang Zheng

Research output: Contribution to journalArticle

Abstract

O-(2-[18F]Fluoroethyl)-l-tyrosine ([18F]FET) has become one of the most successful amino acid tracers for human brain tumor imaging with positron emission tomography (PET). Facile fully automated radiosynthesis and quality control (QC) of [18F]FET using our home-built automated multi-purpose 18F-radiosynthesis module are described. [18F]FET was produced in 75–80 min overall synthesis time with 20–25% radiochemical yield decay corrected to end of bombardment (EOB), based on H[18F]F. The radiochemical and enantiomeric purities were >99%, and the molar activity (Am) was 189–411 GBq/μmol at EOB. The [18F]FET dose meets all QC criteria for clinical use, and is suitable for clinical PET study of brain tumor.

Original languageEnglish (US)
Article number108852
JournalApplied Radiation and Isotopes
Volume154
DOIs
StatePublished - Dec 1 2019

Fingerprint

Positron emission tomography
tyrosine
Positrons
Field effect transistors
quality control
automation
Quality assurance
brain
Quality control
amino acids
Amino acids
Tumors
positrons
Brain
tumors
field effect transistors
Automation
Imaging techniques
bombardment
tomography

Keywords

  • Automation
  • Brain tumor
  • O-(2-[F]Fluoroethyl)--tyrosine ([F]FET)
  • Positron emission tomography (PET)
  • Quality control (QC)
  • Radiosynthesis

ASJC Scopus subject areas

  • Radiation

Cite this

Facile fully automated radiosynthesis and quality control of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) for human brain tumor imaging. / Wang, Min; Glick-Wilson, Barbara E.; Zheng, Qi-Huang.

In: Applied Radiation and Isotopes, Vol. 154, 108852, 01.12.2019.

Research output: Contribution to journalArticle

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abstract = "O-(2-[18F]Fluoroethyl)-l-tyrosine ([18F]FET) has become one of the most successful amino acid tracers for human brain tumor imaging with positron emission tomography (PET). Facile fully automated radiosynthesis and quality control (QC) of [18F]FET using our home-built automated multi-purpose 18F-radiosynthesis module are described. [18F]FET was produced in 75–80 min overall synthesis time with 20–25{\%} radiochemical yield decay corrected to end of bombardment (EOB), based on H[18F]F. The radiochemical and enantiomeric purities were >99{\%}, and the molar activity (Am) was 189–411 GBq/μmol at EOB. The [18F]FET dose meets all QC criteria for clinical use, and is suitable for clinical PET study of brain tumor.",
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