Facile method to sequence cyclic peptides/peptoids via one-pot ring-opening/cleavage reaction

Kang Ju Lee, Hyun Suk Lim

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A facile method for sequence determination of cyclic peptides/peptoids is described. Macrocyclic peptides/peptoids of 3-10 residues were efficiently synthesized through thioether formation. One-pot reaction of thioether-embedded cyclic peptides/peptoids involving cyanogen bromide-mediated ring-opening and cleavage provides linearized molecules, which can be efficiently sequenced by tandem mass spectrometry.

Original languageEnglish (US)
Pages (from-to)5710-5713
Number of pages4
JournalOrganic Letters
Volume16
Issue number21
DOIs
StatePublished - Nov 7 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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