Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase

Qi-Huang Zheng, Xuan Liu, Xiangshu Fei, Ji Quan Wang, Bruce H. Mock, Barbara E. Glick-Wilson, Michael L. Sullivan, Gary Hutchins

Research output: Contribution to journalArticle

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Abstract

[11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[11C]methylation of precursors using [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields.

Original languageEnglish
Pages (from-to)1787-1790
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number10
DOIs
StatePublished - May 19 2003

Fingerprint

Edrophonium
Positron emission tomography
Methylation
Solid Phase Extraction
Acetylcholinesterase
Positron-Emission Tomography
Purification
Imaging techniques
methyl triflate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase. / Zheng, Qi-Huang; Liu, Xuan; Fei, Xiangshu; Wang, Ji Quan; Mock, Bruce H.; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Hutchins, Gary.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 10, 19.05.2003, p. 1787-1790.

Research output: Contribution to journalArticle

Zheng, Qi-Huang ; Liu, Xuan ; Fei, Xiangshu ; Wang, Ji Quan ; Mock, Bruce H. ; Glick-Wilson, Barbara E. ; Sullivan, Michael L. ; Hutchins, Gary. / Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 10. pp. 1787-1790.
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