Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase

Qi Huang Zheng, Xuan Liu, Xiangshu Fei, Ji Quan Wang, Bruce H. Mock, Barbara E. Glick-Wilson, Michael L. Sullivan, Gary D. Hutchins

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

[11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[11C]methylation of precursors using [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields.

Original languageEnglish (US)
Pages (from-to)1787-1790
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number10
DOIs
StatePublished - May 19 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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