Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example

Vivienne J. Zhu, Wanzhu Tu, Marc Rosenman, J. Marc Overhage

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Using data from the Indiana Network of Patient Care (INPC), we analyzed long-term statin adherence patterns and their effects on low-density lipoprotein cholesterol (LDL-C) control among patients with type 2 diabetes. Statin adherence was measured by proportion of days covered (PDC) for a 6-month interval prior to each LDL-C test date. Patient demographic and clinical characteristics were used as covariates for LDL-C control and predictors for statin adherence. From 4,350 eligible subjects, 25,596 6-month PDC and LDL-C level pairs were formed between 2001 and 2009. Rates of suboptimal adherence and suboptimal LDL-C control were 68.5% and 46.6%, respectively. Positive predictors for LDL-C control included adherence to statin (OR: 1.87, p<0.0001) and older age (OR: 1.11, p=0.01). Significant risk factors for non-adherence were young age, female gender, African American race and newly-treated status. This study demonstrated the utility of a health information exchange in health outcome and clinical effectiveness research.

Original languageEnglish (US)
Pages (from-to)947-951
Number of pages5
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
Volume2010
StatePublished - 2010
Externally publishedYes

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LDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipids
Research
African Americans
Type 2 Diabetes Mellitus
Health Information Exchange
Patient Care
Demography
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example",
abstract = "Using data from the Indiana Network of Patient Care (INPC), we analyzed long-term statin adherence patterns and their effects on low-density lipoprotein cholesterol (LDL-C) control among patients with type 2 diabetes. Statin adherence was measured by proportion of days covered (PDC) for a 6-month interval prior to each LDL-C test date. Patient demographic and clinical characteristics were used as covariates for LDL-C control and predictors for statin adherence. From 4,350 eligible subjects, 25,596 6-month PDC and LDL-C level pairs were formed between 2001 and 2009. Rates of suboptimal adherence and suboptimal LDL-C control were 68.5{\%} and 46.6{\%}, respectively. Positive predictors for LDL-C control included adherence to statin (OR: 1.87, p<0.0001) and older age (OR: 1.11, p=0.01). Significant risk factors for non-adherence were young age, female gender, African American race and newly-treated status. This study demonstrated the utility of a health information exchange in health outcome and clinical effectiveness research.",
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AU - Zhu, Vivienne J.

AU - Tu, Wanzhu

AU - Rosenman, Marc

AU - Overhage, J. Marc

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