Factors associated with exacerbation of heart failure include treatment adherence and health literacy skills

Michael Murray, Wanzhu Tu, J. Wu, D. Morrow, F. Smith, D. C. Brater

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

We determined the factors associated with exacerbation of heart failure, using a cohort (n = 192) nested within a randomized trial at a university-affiliated ambulatory practice. Factors associated with emergency or hospital care included left ventricular ejection fraction, hematocrit and serum sodium levels, refill adherence, and the ability to read a prescription label. Refill adherence of <40% was associated with a threefold higher incidence of hospitalization for heart failure than a refill adherence of ≥80% (P = 0.002). In multivariable analysis, prescription label reading skills were associated with a lower incidence of heart failure-specific emergency care (incidence rate ratio, 0.76; 95% confidence interval (CI), 0.19-0.69), and participants with adequate health literacy had a lower risk of hospitalization for heart failure (incidence rate ratio, 0.34; 95% CI, 0.15-0.76). We conclude that inadequate treatment adherence and health literacy skills are key factors in the exacerbation of heart failure. These findings emphasize the need for careful instruction of patients about their medications.

Original languageEnglish
Pages (from-to)651-658
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume85
Issue number6
DOIs
StatePublished - Jun 2009

Fingerprint

Health Literacy
Heart Failure
Incidence
Prescriptions
Hospitalization
Confidence Intervals
Therapeutics
Emergency Medical Services
Hematocrit
Stroke Volume
Reading
Emergencies
Sodium
Serum

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Factors associated with exacerbation of heart failure include treatment adherence and health literacy skills. / Murray, Michael; Tu, Wanzhu; Wu, J.; Morrow, D.; Smith, F.; Brater, D. C.

In: Clinical Pharmacology and Therapeutics, Vol. 85, No. 6, 06.2009, p. 651-658.

Research output: Contribution to journalArticle

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