Factors Associated With Retinal Vessel Diameters in an Elderly Population

the Thessaloniki Eye Study

Nikolaos Dervenis, Anne L. Coleman, Alon Harris, M. Roy Wilson, Fei Yu, Eleftherios Anastasopoulos, Panayiota Founti, Theofanis Pappas, Vassilis Kilintzis, Fotis Topouzis

Research output: Contribution to journalArticle

Abstract

Purpose: To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. Methods: Cross-sectional population-based study (age ≥ 60 years). Subjects with glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from the analyses. Retinal vessel diameters were measured using the IVAN software, and measurements were summarized to central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole to venule ratio (AVR). Results: The analysis included 1614 subjects. The hypertensive group showed lower values of CRAE (P = 0.033) and AVR (P = 0.0351) compared to the normal blood pressure (BP) group. On the contrary, the group having normal BP under antihypertensive treatment did not have different values compared to the normal BP group. Diastolic BP (per mm Hg) was negatively associated with CRAE (P < 0.0001) and AVR (P < 0.0001), while systolic BP (per mm Hg) was positively associated with CRAE (P = 0.001) and AVR (P = 0.0096). Other factors significantly associated included age, sex, alcohol, smoking, cardiovascular disease history, ophthalmic medication, weight, and IOP; differences were observed in a stratified analysis based on BP medication use. Conclusions: Our study confirms previous reports about the association of age and BP with vessel diameters. The negative correlation between BP and CRAE seems to be guided by the effect of diastolic BP as higher systolic BP is independently associated with higher values of CRAE. The association of BP status with retinal vessel diameters is determined by diastolic BP status in our population. Multiple other factors are also independently associated with retinal vessel diameters.

Original languageEnglish (US)
Pages (from-to)2208-2217
Number of pages10
JournalInvestigative ophthalmology & visual science
Volume60
Issue number6
DOIs
StatePublished - May 1 2019

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Retinal Vessels
Blood Pressure
Retinal Artery
Population
Venules
Arterioles
Blood Group Antigens
Retinal Vein
Macular Degeneration
Diabetic Retinopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Factors Associated With Retinal Vessel Diameters in an Elderly Population : the Thessaloniki Eye Study. / Dervenis, Nikolaos; Coleman, Anne L.; Harris, Alon; Wilson, M. Roy; Yu, Fei; Anastasopoulos, Eleftherios; Founti, Panayiota; Pappas, Theofanis; Kilintzis, Vassilis; Topouzis, Fotis.

In: Investigative ophthalmology & visual science, Vol. 60, No. 6, 01.05.2019, p. 2208-2217.

Research output: Contribution to journalArticle

Dervenis, N, Coleman, AL, Harris, A, Wilson, MR, Yu, F, Anastasopoulos, E, Founti, P, Pappas, T, Kilintzis, V & Topouzis, F 2019, 'Factors Associated With Retinal Vessel Diameters in an Elderly Population: the Thessaloniki Eye Study', Investigative ophthalmology & visual science, vol. 60, no. 6, pp. 2208-2217. https://doi.org/10.1167/iovs.18-26276
Dervenis, Nikolaos ; Coleman, Anne L. ; Harris, Alon ; Wilson, M. Roy ; Yu, Fei ; Anastasopoulos, Eleftherios ; Founti, Panayiota ; Pappas, Theofanis ; Kilintzis, Vassilis ; Topouzis, Fotis. / Factors Associated With Retinal Vessel Diameters in an Elderly Population : the Thessaloniki Eye Study. In: Investigative ophthalmology & visual science. 2019 ; Vol. 60, No. 6. pp. 2208-2217.
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AU - Wilson, M. Roy

AU - Yu, Fei

AU - Anastasopoulos, Eleftherios

AU - Founti, Panayiota

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AU - Kilintzis, Vassilis

AU - Topouzis, Fotis

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N2 - Purpose: To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. Methods: Cross-sectional population-based study (age ≥ 60 years). Subjects with glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from the analyses. Retinal vessel diameters were measured using the IVAN software, and measurements were summarized to central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and arteriole to venule ratio (AVR). Results: The analysis included 1614 subjects. The hypertensive group showed lower values of CRAE (P = 0.033) and AVR (P = 0.0351) compared to the normal blood pressure (BP) group. On the contrary, the group having normal BP under antihypertensive treatment did not have different values compared to the normal BP group. Diastolic BP (per mm Hg) was negatively associated with CRAE (P < 0.0001) and AVR (P < 0.0001), while systolic BP (per mm Hg) was positively associated with CRAE (P = 0.001) and AVR (P = 0.0096). Other factors significantly associated included age, sex, alcohol, smoking, cardiovascular disease history, ophthalmic medication, weight, and IOP; differences were observed in a stratified analysis based on BP medication use. Conclusions: Our study confirms previous reports about the association of age and BP with vessel diameters. The negative correlation between BP and CRAE seems to be guided by the effect of diastolic BP as higher systolic BP is independently associated with higher values of CRAE. The association of BP status with retinal vessel diameters is determined by diastolic BP status in our population. Multiple other factors are also independently associated with retinal vessel diameters.

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