Factors associated with seizure freedom in the surgical resection of glioneuronal tumors

Dario J. Englot, Mitchel S. Berger, Nicholas Barbaro, Edward F. Chang

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Purpose: Gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumors (DNETs) are low-grade brain tumors of glioneuronal origin that commonly present with seizures. Achieving seizure control in patients with glioneuronal tumors remains underappreciated, as tumor-related epilepsy significantly affects patients' quality-of-life. Methods: We performed a quantitative and comprehensive systematic literature review of seizure outcomes after surgical resection of GGs and DNETs associated with seizures. We evaluated 910 patients from 39 studies, and stratified outcomes according to several potential prognostic variables. Key Findings: Overall, 80% of patients were seizure-free after surgery (Engel class I), whereas 20% continued to have seizures (Engel class II-IV). We observed significantly higher rates of seizure-freedom in patients with ≤1 year duration of epilepsy compared to those with >1 year of seizures [odds ratio (OR) 9.48; 95% confidence interval (CI) 2.26-39.66], and with gross-total resection over subtotal lesionectomy (OR 5.34; 95% CI 3.61-7.89). In addition, the presence of secondarily generalized seizures preoperatively predicted a lower rate of seizure-freedom after surgery (OR 0.40; 95% CI 0.24-0.66). Outcomes did not differ significantly between adults and children, patients with temporal lobe versus extratemporal tumors, pathologic diagnosis of GG versus DNET, medically controlled versus refractory seizures, or with the use of electrocorticography (ECoG). Extended resection of temporal lobe tumors, with hippocampectomy and/or corticectomy, conferred additional benefit. Significance: These results suggest that early operative intervention and gross-total resection are critically important factors in achieving seizure-freedom, and thus improving quality-of-life, in patients with glioneuronal tumors causing epilepsy.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalEpilepsia
Volume53
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Seizures
Neoplasms
Ganglioglioma
Neuroepithelial Neoplasms
Epilepsy
Odds Ratio
Temporal Lobe
Confidence Intervals
Quality of Life
Brain Neoplasms
Outcome Assessment (Health Care)

Keywords

  • Dysembryoplastic neuroepithelial tumor
  • Epilepsy
  • Ganglioglioma
  • Generalized
  • Seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Factors associated with seizure freedom in the surgical resection of glioneuronal tumors. / Englot, Dario J.; Berger, Mitchel S.; Barbaro, Nicholas; Chang, Edward F.

In: Epilepsia, Vol. 53, No. 1, 01.2012, p. 51-57.

Research output: Contribution to journalArticle

Englot, Dario J. ; Berger, Mitchel S. ; Barbaro, Nicholas ; Chang, Edward F. / Factors associated with seizure freedom in the surgical resection of glioneuronal tumors. In: Epilepsia. 2012 ; Vol. 53, No. 1. pp. 51-57.
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