Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer

P. Veeraraghavan Ramachandran, Matthew A. Helppi, Arlie L. Lehmkuhler, Jennifer M. Marchi, C. Schmidt, Michele Yip-Schneider

Research output: Contribution to journalArticle

Abstract

A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the possibility to lactonize to α-methylene-γ-butyrolactones is as important. The substitution pattern and the number of carbons between the hydroxy and ester moieties also influence the bio-activity.

Original languageEnglish (US)
Pages (from-to)4270-4273
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number19
DOIs
StatePublished - Oct 1 2015

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Cytotoxicity
Pancreatic Neoplasms
Esters
Bioactivity
Substitution reactions
Carbon
Cells
Cell Line

Keywords

  • Cytotoxicity
  • Hydroxy esters
  • Lactonization
  • Pancreatic
  • Pro-drug

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer. / Ramachandran, P. Veeraraghavan; Helppi, Matthew A.; Lehmkuhler, Arlie L.; Marchi, Jennifer M.; Schmidt, C.; Yip-Schneider, Michele.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 19, 01.10.2015, p. 4270-4273.

Research output: Contribution to journalArticle

Ramachandran, P. Veeraraghavan ; Helppi, Matthew A. ; Lehmkuhler, Arlie L. ; Marchi, Jennifer M. ; Schmidt, C. ; Yip-Schneider, Michele. / Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer. In: Bioorganic and Medicinal Chemistry Letters. 2015 ; Vol. 25, No. 19. pp. 4270-4273.
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