Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer

P. Veeraraghavan Ramachandran, Matthew A. Helppi, Arlie L. Lehmkuhler, Jennifer M. Marchi, C. Max Schmidt, Michele T. Yip-Schneider

Research output: Contribution to journalArticle


A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the possibility to lactonize to α-methylene-γ-butyrolactones is as important. The substitution pattern and the number of carbons between the hydroxy and ester moieties also influence the bio-activity.

Original languageEnglish (US)
Pages (from-to)4270-4273
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
StatePublished - Oct 1 2015



  • Cytotoxicity
  • Hydroxy esters
  • Lactonization
  • Pancreatic
  • Pro-drug

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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