Failure of lndomethacin to Inhibit Saralasin-Stimulated Plasma Renin Activity in Conscious Dogs with Mild Sodium Depletion (41216)

J. R. Dietz, J. O. Davis, R. H. Freeman, S. F. Echtenkamp, D. Villarreal

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The hypothesis that prostaglandins play a role in the angiotensin II control mechanism for renin release was examined by interrupting the short-loop negative feedback of angiotensin II on the JG cells with the competitive angiotensin II antagonist saralasin. Mildly sodium-depleted conscious dogs received either indomethacin, or the vehicle alone followed by an intravenous infusion of saralasin. Saralasin produced equivalent increases in PRA in the vehicle- and indomethacin-treated groups with no detectable change in arterial pressure. Plasma renin activity increased in the indomethacin-treated group despite a 58% fall in the rate of excretion of PGE2. These results suggest that in the conscious dog renal prostaglandins do not play an appreciable role in angiotensin II feedback control of renin release.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume167
Issue number4
DOIs
StatePublished - Sep 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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