Failure to Confirm Muscarinic Receptors on Skin Fibroblasts

Robert H. Lenox, Robert J. Hitzemann, Elliott Richelson, John R. Kelsoe, John R. Kelsoe, J. Christian Gillin, David S. Janowsky, Joan Heller Brown, S. Craig Risch, Barry Lumkin, Elliot S. Gershon, N. Suzan Nadi, John I. Nurnberger, Wade H. Berrettini

Research output: Contribution to journalLetter

15 Scopus citations

Abstract

To the Editor: In the July 26 issue, Nadi et al.1 reported that primary cultures of human skin fibroblasts “possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist.” The authors also indicated that the fibroblasts of patients with a major affective disorder (or a relative with a history of a major or minor depressive disorder) had a significantly higher density of muscarinic binding sites as determined by the binding of the radioactive antagonist ligand [3H]quinuclidinyl benzilate ([3H]QNB) than did control subjects. They.

Original languageEnglish (US)
Pages (from-to)861-862
Number of pages2
JournalNew England Journal of Medicine
Volume312
Issue number13
DOIs
StatePublished - Mar 28 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Lenox, R. H., Hitzemann, R. J., Richelson, E., Kelsoe, J. R., Kelsoe, J. R., Gillin, J. C., Janowsky, D. S., Brown, J. H., Risch, S. C., Lumkin, B., Gershon, E. S., Nadi, N. S., Nurnberger, J. I., & Berrettini, W. H. (1985). Failure to Confirm Muscarinic Receptors on Skin Fibroblasts. New England Journal of Medicine, 312(13), 861-862. https://doi.org/10.1056/NEJM198503283121319