False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies

L. Joseph Wheat, P. Connolly, M. Durkin, B. K. Book, A. J. Tector, J. Fridell, M. D. Pescovitz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin®) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin®, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalTransplant Infectious Disease
Volume6
Issue number1
DOIs
StatePublished - Mar 2004

Fingerprint

Histoplasma
Antilymphocyte Serum
Antibodies
Allografts
Rabbits
Physicians
Antigens
thymoglobulin

Keywords

  • Antigenemia
  • Antithymocyte globulin
  • False-positive
  • HARA
  • Histoplasmosis
  • Transplant

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology

Cite this

Wheat, L. J., Connolly, P., Durkin, M., Book, B. K., Tector, A. J., Fridell, J., & Pescovitz, M. D. (2004). False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies. Transplant Infectious Disease, 6(1), 23-27. https://doi.org/10.1111/j.1399-3062.2004.00045.x

False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies. / Wheat, L. Joseph; Connolly, P.; Durkin, M.; Book, B. K.; Tector, A. J.; Fridell, J.; Pescovitz, M. D.

In: Transplant Infectious Disease, Vol. 6, No. 1, 03.2004, p. 23-27.

Research output: Contribution to journalArticle

Wheat, LJ, Connolly, P, Durkin, M, Book, BK, Tector, AJ, Fridell, J & Pescovitz, MD 2004, 'False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies', Transplant Infectious Disease, vol. 6, no. 1, pp. 23-27. https://doi.org/10.1111/j.1399-3062.2004.00045.x
Wheat, L. Joseph ; Connolly, P. ; Durkin, M. ; Book, B. K. ; Tector, A. J. ; Fridell, J. ; Pescovitz, M. D. / False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies. In: Transplant Infectious Disease. 2004 ; Vol. 6, No. 1. pp. 23-27.
@article{89d6dacc11484392966222f245c832fb,
title = "False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies",
abstract = "False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin{\circledR}) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin{\circledR}, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9{\%}) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.",
keywords = "Antigenemia, Antithymocyte globulin, False-positive, HARA, Histoplasmosis, Transplant",
author = "Wheat, {L. Joseph} and P. Connolly and M. Durkin and Book, {B. K.} and Tector, {A. J.} and J. Fridell and Pescovitz, {M. D.}",
year = "2004",
month = "3",
doi = "10.1111/j.1399-3062.2004.00045.x",
language = "English",
volume = "6",
pages = "23--27",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies

AU - Wheat, L. Joseph

AU - Connolly, P.

AU - Durkin, M.

AU - Book, B. K.

AU - Tector, A. J.

AU - Fridell, J.

AU - Pescovitz, M. D.

PY - 2004/3

Y1 - 2004/3

N2 - False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin®) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin®, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.

AB - False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin®) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin®, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.

KW - Antigenemia

KW - Antithymocyte globulin

KW - False-positive

KW - HARA

KW - Histoplasmosis

KW - Transplant

UR - http://www.scopus.com/inward/record.url?scp=3242687888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242687888&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3062.2004.00045.x

DO - 10.1111/j.1399-3062.2004.00045.x

M3 - Article

C2 - 15225223

AN - SCOPUS:3242687888

VL - 6

SP - 23

EP - 27

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 1

ER -