Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees

Jennifer L. Payne, Dean F. Mackinnon, Francis M. Mondimore, Melvin G. Mcinnis, Barbara Schweizer, Rachel B. Zamoiski, Francis J. Mcmahon, John Nurnberger, John P. Rice, William Scheftner, William Coryell, Wade H. Berrettini, John R. Kelsoe, William Byerley, Elliot S. Gershon, J. Raymond Depaulo, James B. Potash

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives: We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees. Methods: A total of 1,130 women were interviewed with the Diagnostic Interview for Genetic Studies as part of the National Institute of Mental Health (NIMH) Genetics Initiative Bipolar Disorder Collaborative Study and were asked whether they had ever experienced mood symptoms within four weeks postpartum. Women were also asked whether either of two major depressive episodes described in detail occurred postpartum. We examined the odds of postpartum mood symptoms in female siblings, who had previously been pregnant and had a diagnosis of bipolar I, bipolar II, or schizoaffective (bipolar type) disorders (n = 303), given one or more relatives with postpartum mood symptoms. Results: The odds ratio for familial aggregation of postpartum mood symptoms was 2.31 (p=0.011) in an Any Mood Symptoms analysis (n = 304) and increased to 2.71 (p = 0.005) when manic symptoms were excluded, though this was not significantly different from the Any Mood Symptoms analysis. We also examined familial aggregation of postpartum major depressive episodes; however, the number of subjects was small. Conclusions: Limitations of the study include the retrospective interview, the fact that the data were collected for other purposes and the inability to control for such factors as medication use. Taken together with previous studies, these data provide support for the hypothesis that there may be a genetic basis for the trait of postpartum mood symptoms generally and postpartum depressive symptoms in particular in women with bipolar disorder. Genetic linkage and association studies incorporating this trait are warranted.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalBipolar Disorders
Volume10
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Pedigree
Bipolar Disorder
Postpartum Period
Interviews
Depression
National Institute of Mental Health (U.S.)
Genetic Linkage
Genetic Association Studies
Psychotic Disorders
Siblings
Retrospective Studies
Odds Ratio

Keywords

  • Bipolar
  • Genetics
  • Postpartum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Payne, J. L., Mackinnon, D. F., Mondimore, F. M., Mcinnis, M. G., Schweizer, B., Zamoiski, R. B., ... Potash, J. B. (2008). Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disorders, 10(1), 38-44. https://doi.org/10.1111/j.1399-5618.2008.00455.x

Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. / Payne, Jennifer L.; Mackinnon, Dean F.; Mondimore, Francis M.; Mcinnis, Melvin G.; Schweizer, Barbara; Zamoiski, Rachel B.; Mcmahon, Francis J.; Nurnberger, John; Rice, John P.; Scheftner, William; Coryell, William; Berrettini, Wade H.; Kelsoe, John R.; Byerley, William; Gershon, Elliot S.; Depaulo, J. Raymond; Potash, James B.

In: Bipolar Disorders, Vol. 10, No. 1, 02.2008, p. 38-44.

Research output: Contribution to journalArticle

Payne, JL, Mackinnon, DF, Mondimore, FM, Mcinnis, MG, Schweizer, B, Zamoiski, RB, Mcmahon, FJ, Nurnberger, J, Rice, JP, Scheftner, W, Coryell, W, Berrettini, WH, Kelsoe, JR, Byerley, W, Gershon, ES, Depaulo, JR & Potash, JB 2008, 'Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees', Bipolar Disorders, vol. 10, no. 1, pp. 38-44. https://doi.org/10.1111/j.1399-5618.2008.00455.x
Payne JL, Mackinnon DF, Mondimore FM, Mcinnis MG, Schweizer B, Zamoiski RB et al. Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disorders. 2008 Feb;10(1):38-44. https://doi.org/10.1111/j.1399-5618.2008.00455.x
Payne, Jennifer L. ; Mackinnon, Dean F. ; Mondimore, Francis M. ; Mcinnis, Melvin G. ; Schweizer, Barbara ; Zamoiski, Rachel B. ; Mcmahon, Francis J. ; Nurnberger, John ; Rice, John P. ; Scheftner, William ; Coryell, William ; Berrettini, Wade H. ; Kelsoe, John R. ; Byerley, William ; Gershon, Elliot S. ; Depaulo, J. Raymond ; Potash, James B. / Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. In: Bipolar Disorders. 2008 ; Vol. 10, No. 1. pp. 38-44.
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