Familial cerebral amyloid angiopathy related to stroke and dementia

B. Frangione, T. Révész, R. Vidal, J. Holton, T. Lashley, H. Houlden, N. Wood, A. Rostagno, G. Plant, J. Ghiso

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Abstract

The term cerebral amyloid angiopathy (CAA) refers to the specific deposition of amyloid fibrils in the walls of leptomeningeal and cortical arteries, arterioles and, although less frequently, in capillaries and veins. It is commonly associated with Alzheimer's disease. Down syndrome and normal aging, as well as with a variety of familial conditions related to stroke and/or dementia: hereditary cerebral hemorrhage with amyloidosis of Icelandic type (HCHWA-I), various inherited disorders linked to Aβ mutants (including the Dutch variant of HCHWA), and the recently described chromosome 13 familial dementia in British and Danish kindreds. This review focuses on four different types of hereditary CAA, emphasizing the notion that CAA is not only related to stroke but also to neurodegeneration and dementia of the Alzheimer's type.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalAmyloid
Volume8
Issue numberSUPPL. 1
StatePublished - Oct 3 2001

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Keywords

  • Amyloid angiopathy
  • Cerebra
  • Dementia
  • Familial
  • Stroke

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Frangione, B., Révész, T., Vidal, R., Holton, J., Lashley, T., Houlden, H., Wood, N., Rostagno, A., Plant, G., & Ghiso, J. (2001). Familial cerebral amyloid angiopathy related to stroke and dementia. Amyloid, 8(SUPPL. 1), 36-42.