Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1

William Groh, Miriam R. Lowe, Zachary Simmons, Deepak Bhakta, Robert Pascuzzi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Myotonic dystrophy type 1 (DM1) is associated with both skeletal and cardiac muscle involvement. The aim of the present study was to determine whether familial clustering is observed in the severity of muscle involvement in DM1. We evaluated 51 sibling groups constituting 112 patients with genetically-verified DM1. The siblings were similar to each other in age, cytosine-thymine-guanine (CTG) repeat length, age at disease onset, muscular impairment rating score, and electrocardiographic markers of cardiac conduction disease. After adjusting for the similarities between siblings in age and CTG repeat length, the siblings remained similar to each other in measures of both skeletal and cardiac muscle involvement. These results suggest that factors other than CTG repeat length play a role in the severity and progression of the degenerative skeletal and cardiac muscle disease in DM1.

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalMuscle and Nerve
Volume31
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Myotonic Dystrophy
Thymine
Cluster Analysis
Siblings
Cytosine
Guanine
Myocardium
Skeletal Muscle
Heart Diseases
Muscular Diseases
Age of Onset
Muscles

Keywords

  • Arrhythmias
  • Cardiomyopathy
  • CTG repeat length
  • Familial clustering
  • Genetics
  • Myotonic dystrophy type 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1. / Groh, William; Lowe, Miriam R.; Simmons, Zachary; Bhakta, Deepak; Pascuzzi, Robert.

In: Muscle and Nerve, Vol. 31, No. 6, 06.2005, p. 719-724.

Research output: Contribution to journalArticle

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