Familial gastroesophageal reflux and development of Barrett's esophagus

D. W. Crabb, M. A. Berk, T. R. Hall, P. M. Conneally, A. A. Biegel, G. A. Lehman

Research output: Contribution to journalArticle

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The family of an elderly man with Barrett's esophagus was examined for gastroesophageal reflux and development of Barrett's esophagus. All 5 living children have gastroesophageal reflux or esophagitis, or both, and 3 have unequivocal Barrett's esophagus. Two third-generation descendents have gastroesophageal reflux. This pattern suggests autosomal dominant transmission of the gastroesophageal reflux trait. The family also has a high prevalence of cancer, which may represent the cancer family syndrome.

Original languageEnglish (US)
Pages (from-to)52-54
Number of pages3
JournalAnnals of internal medicine
Issue number1
StatePublished - Jan 1 1985


ASJC Scopus subject areas

  • Internal Medicine

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