Familial risk of lung cancer among nonsmokers and their relatives

Ann G. Schwartz, Ping Yang, G. Marie Swanson

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The role of family history of lung cancer in predicting lung cancer risk among nonsmokers and their relatives was evaluated in a population-based family study conducted in metropolitan Detroit. Lung cancer risk factor data were collected through telephone interviews with 257 nonsmoking lung cancer cases 40-84 years of age diagnosed between 1984 and 1987, their 2,252 relatives, 277 nonsmoking controls, and their 2,408 relatives. Lung cancer in a first-degree relative was associated with a 7.2-fold (95% confidence interval 1.3-39.7) increased risk of lung cancer among nonsmokers in the 40- to 59-year-old age group. This significant increased risk remained after adjustment for the smoking, occupational, and medical history of each family member (relative risk = 6.1, 95% confidence interval 1.1-33.4). Offspring of nonsmoking cases comprised another lung cancer high risk group (relative risk = 7.2, 95% confidence interval 0.5-103). A positive family history did not increase lung cancer risk among nonsmokers 60-84 years of age or their relatives. These findings suggest that susceptibility to lung cancer in families of nonsmoking cases may be evident only in a subset of relatives of early-onset nonsmoking cases.

Original languageEnglish (US)
Pages (from-to)554-562
Number of pages9
JournalAmerican Journal of Epidemiology
Volume144
Issue number6
StatePublished - Sep 15 1996
Externally publishedYes

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Lung Neoplasms
Confidence Intervals
Age Groups
Smoking
Interviews
Population

Keywords

  • family health
  • genetics
  • lung diseases
  • lung neoplasms
  • risk

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schwartz, A. G., Yang, P., & Swanson, G. M. (1996). Familial risk of lung cancer among nonsmokers and their relatives. American Journal of Epidemiology, 144(6), 554-562.

Familial risk of lung cancer among nonsmokers and their relatives. / Schwartz, Ann G.; Yang, Ping; Swanson, G. Marie.

In: American Journal of Epidemiology, Vol. 144, No. 6, 15.09.1996, p. 554-562.

Research output: Contribution to journalArticle

Schwartz, AG, Yang, P & Swanson, GM 1996, 'Familial risk of lung cancer among nonsmokers and their relatives', American Journal of Epidemiology, vol. 144, no. 6, pp. 554-562.
Schwartz, Ann G. ; Yang, Ping ; Swanson, G. Marie. / Familial risk of lung cancer among nonsmokers and their relatives. In: American Journal of Epidemiology. 1996 ; Vol. 144, No. 6. pp. 554-562.
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