Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking

Laura Jean Bierut, John P. Rice, Howard J. Edenberg, Alison Goate, Tatiana Foroud, C. Robert Cloninger, Henri Begleiter, P. Michael Conneally, Raymond R. Crowe, Victor Hesselbrock, Ting Kai Li, John I. Nurnberger, Bernice Porjesz, Marc A. Schuckit, Theodore Reich

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

A recent study showed an association between the dopamine D2 receptor gene (DRD2) and smoking. The purpose of this study was to determine if the familial transmission of smoking is linked to variation at the DRD2 locus in a genetically informative sample. Subjects were identified in alcohol treatment centers and their relatives were recruited for study. All subjects were interviewed to assess alcohol dependence, smoking habits, and psychiatric disorders. Two polymorphisms within the DRD2 gene were analyzed, including the TaqIA polymorphism. The sample consisted of 138 nuclear families with at least one offspring with habitual smoking, and analysis was by the transmission disequilibrium test (TDT), which avoids problems due to population stratification. There was no significant difference in the frequency between DRD2 alleles transmitted and not transmitted to habitual smokers. There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes 'ever smoker' or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume90
Issue number4
DOIs
StatePublished - Feb 17 2000

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Dopamine D2 Receptors
Smoking
Genes
Alcoholism
Alleles
Nuclear Family
Habits
Psychiatry
Alcohols
Phenotype
Population

Keywords

  • Dopamine
  • DRD2
  • Family study
  • Genetics
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. / Bierut, Laura Jean; Rice, John P.; Edenberg, Howard J.; Goate, Alison; Foroud, Tatiana; Cloninger, C. Robert; Begleiter, Henri; Conneally, P. Michael; Crowe, Raymond R.; Hesselbrock, Victor; Li, Ting Kai; Nurnberger, John I.; Porjesz, Bernice; Schuckit, Marc A.; Reich, Theodore.

In: American Journal of Medical Genetics, Vol. 90, No. 4, 17.02.2000, p. 299-302.

Research output: Contribution to journalArticle

Bierut, LJ, Rice, JP, Edenberg, HJ, Goate, A, Foroud, T, Cloninger, CR, Begleiter, H, Conneally, PM, Crowe, RR, Hesselbrock, V, Li, TK, Nurnberger, JI, Porjesz, B, Schuckit, MA & Reich, T 2000, 'Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking', American Journal of Medical Genetics, vol. 90, no. 4, pp. 299-302. https://doi.org/10.1002/(SICI)1096-8628(20000214)90:4<299::AID-AJMG7>3.0.CO;2-Y
Bierut, Laura Jean ; Rice, John P. ; Edenberg, Howard J. ; Goate, Alison ; Foroud, Tatiana ; Cloninger, C. Robert ; Begleiter, Henri ; Conneally, P. Michael ; Crowe, Raymond R. ; Hesselbrock, Victor ; Li, Ting Kai ; Nurnberger, John I. ; Porjesz, Bernice ; Schuckit, Marc A. ; Reich, Theodore. / Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. In: American Journal of Medical Genetics. 2000 ; Vol. 90, No. 4. pp. 299-302.
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