Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country

Gladys Acuña-González, Carlo E. Medina-Solís, Gerardo Maupomé, Mauricio Escoffie-Ramírez, Jesús Hernández-Romano, María de L. Márquez-Corona, Arturo J. Islas-Márquez, Juan J. Villalobos-Rodelo

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Introduction: From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide. Objective: Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate. Material and methods: A case-control study was carried out with 208 cases of non-syndromic cleft lip with or without cleft palate, and matched by age and sex with 416 controls. Cases were patients attending a referral clinic from 2002 through 2004 in Campeche, Mexico. A questionnaire was administered to collect sociodemographic and socioeconomic variables as well as familial background relevant to non-syndromic cleft lip with or without cleft palate. Conditional logistic regression models were used; adjusted odds ratios and 95% confidence intervals were calculated. Results: In the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of Campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. Prenatal care consisting of vitamin supplementation was a protective factor for non-syndromic cleft lip with or without cleft palate (odds ratio=0.29). Conclusions: A "social gradient in health" was seen to link oral malformation with diet components, and several socioeconomic and socio-demographic factors broadly encompassed in low socioeconomic status. Further characterization of risk factors will guide the assemblage of a pro-active counseling and prevention program for families at risk for non-syndromic cleft lip and cleft palate.

Original languageEnglish (US)
Pages (from-to)381-391
Number of pages11
JournalBiomedica
Volume31
Issue number3
StatePublished - Dec 1 2011

Keywords

  • Cleft lip
  • Cleft palate
  • Epidemiology
  • Folic acid
  • Mexico
  • Risk factors
  • Socioeconomic factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Acuña-González, G., Medina-Solís, C. E., Maupomé, G., Escoffie-Ramírez, M., Hernández-Romano, J., Márquez-Corona, M. D. L., Islas-Márquez, A. J., & Villalobos-Rodelo, J. J. (2011). Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country. Biomedica, 31(3), 381-391.