Family history of alcoholism and the human brain response to oral sucrose

William J.A. Eiler, Mario Dzemidzic, Christina M. Soeurt, Claire R. Carron, Brandon G. Oberlin, Robert V. Considine, Jaroslaw Harezlak, David A. Kareken

Research output: Contribution to journalArticle

Abstract

A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level dependent (BOLD) activation to high- and low-concentration sweet solutions in subjects who are either positive (FHP) or negative (FHN) for a family history of alcoholism. Seventy-four non-treatment seeking, community-recruited, healthy volunteers (22.8 ± 1.6 SD years; 43% men) rated a range of sucrose concentrations in a taste test and underwent functional magnetic resonance imaging (fMRI) during oral delivery of water, 0.83 M, and 0.10 M sucrose. Sucrose compared to water produced robust activation in primary gustatory cortex, ventral insula, amygdala, and ventral striatum. FHP subjects displayed greater bilateral amygdala activation than FHN subjects in the low sucrose concentration (0.10 M). In secondary analyses, the right amygdala response to the 0.10 M sucrose was greatest in FHP women. When accounting for group differences in drinks per week, the family history groups remained significantly different in their right amygdala response to 0.10 M sucrose. Our findings suggest that the brain response to oral sucrose differs with a family history of alcoholism, and that this response to a mildly reinforcing primary reward might be an endophenotypic marker of alcoholism risk.

LanguageEnglish (US)
Pages1036-1046
Number of pages11
JournalNeuroImage: Clinical
Volume17
DOIs
StatePublished - Jan 1 2018

Fingerprint

Alcoholism
Sucrose
Amygdala
Brain
Pleasure
Water
Reward
Alcohol Drinking
Healthy Volunteers
Alcohols
Magnetic Resonance Imaging

Keywords

  • Alcohol
  • fMRI
  • Gustatory
  • Sweet
  • Taste

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Family history of alcoholism and the human brain response to oral sucrose. / Eiler, William J.A.; Dzemidzic, Mario; Soeurt, Christina M.; Carron, Claire R.; Oberlin, Brandon G.; Considine, Robert V.; Harezlak, Jaroslaw; Kareken, David A.

In: NeuroImage: Clinical, Vol. 17, 01.01.2018, p. 1036-1046.

Research output: Contribution to journalArticle

Eiler WJA, Dzemidzic M, Soeurt CM, Carron CR, Oberlin BG, Considine RV et al. Family history of alcoholism and the human brain response to oral sucrose. NeuroImage: Clinical. 2018 Jan 1;17:1036-1046. Available from, DOI: 10.1016/j.nicl.2017.12.019
Eiler, William J.A. ; Dzemidzic, Mario ; Soeurt, Christina M. ; Carron, Claire R. ; Oberlin, Brandon G. ; Considine, Robert V. ; Harezlak, Jaroslaw ; Kareken, David A./ Family history of alcoholism and the human brain response to oral sucrose. In: NeuroImage: Clinical. 2018 ; Vol. 17. pp. 1036-1046
@article{9681a0b0ecbc4cceaf07dcdff06fd167,
title = "Family history of alcoholism and the human brain response to oral sucrose",
abstract = "A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level dependent (BOLD) activation to high- and low-concentration sweet solutions in subjects who are either positive (FHP) or negative (FHN) for a family history of alcoholism. Seventy-four non-treatment seeking, community-recruited, healthy volunteers (22.8 ± 1.6 SD years; 43{\%} men) rated a range of sucrose concentrations in a taste test and underwent functional magnetic resonance imaging (fMRI) during oral delivery of water, 0.83 M, and 0.10 M sucrose. Sucrose compared to water produced robust activation in primary gustatory cortex, ventral insula, amygdala, and ventral striatum. FHP subjects displayed greater bilateral amygdala activation than FHN subjects in the low sucrose concentration (0.10 M). In secondary analyses, the right amygdala response to the 0.10 M sucrose was greatest in FHP women. When accounting for group differences in drinks per week, the family history groups remained significantly different in their right amygdala response to 0.10 M sucrose. Our findings suggest that the brain response to oral sucrose differs with a family history of alcoholism, and that this response to a mildly reinforcing primary reward might be an endophenotypic marker of alcoholism risk.",
keywords = "Alcohol, fMRI, Gustatory, Sweet, Taste",
author = "Eiler, {William J.A.} and Mario Dzemidzic and Soeurt, {Christina M.} and Carron, {Claire R.} and Oberlin, {Brandon G.} and Considine, {Robert V.} and Jaroslaw Harezlak and Kareken, {David A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.nicl.2017.12.019",
language = "English (US)",
volume = "17",
pages = "1036--1046",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Family history of alcoholism and the human brain response to oral sucrose

AU - Eiler,William J.A.

AU - Dzemidzic,Mario

AU - Soeurt,Christina M.

AU - Carron,Claire R.

AU - Oberlin,Brandon G.

AU - Considine,Robert V.

AU - Harezlak,Jaroslaw

AU - Kareken,David A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level dependent (BOLD) activation to high- and low-concentration sweet solutions in subjects who are either positive (FHP) or negative (FHN) for a family history of alcoholism. Seventy-four non-treatment seeking, community-recruited, healthy volunteers (22.8 ± 1.6 SD years; 43% men) rated a range of sucrose concentrations in a taste test and underwent functional magnetic resonance imaging (fMRI) during oral delivery of water, 0.83 M, and 0.10 M sucrose. Sucrose compared to water produced robust activation in primary gustatory cortex, ventral insula, amygdala, and ventral striatum. FHP subjects displayed greater bilateral amygdala activation than FHN subjects in the low sucrose concentration (0.10 M). In secondary analyses, the right amygdala response to the 0.10 M sucrose was greatest in FHP women. When accounting for group differences in drinks per week, the family history groups remained significantly different in their right amygdala response to 0.10 M sucrose. Our findings suggest that the brain response to oral sucrose differs with a family history of alcoholism, and that this response to a mildly reinforcing primary reward might be an endophenotypic marker of alcoholism risk.

AB - A heightened hedonic response to sweet tastes has been associated with increased alcohol preference and alcohol consumption in both humans and animals. The principal goal of this study was to examine blood oxygenation level dependent (BOLD) activation to high- and low-concentration sweet solutions in subjects who are either positive (FHP) or negative (FHN) for a family history of alcoholism. Seventy-four non-treatment seeking, community-recruited, healthy volunteers (22.8 ± 1.6 SD years; 43% men) rated a range of sucrose concentrations in a taste test and underwent functional magnetic resonance imaging (fMRI) during oral delivery of water, 0.83 M, and 0.10 M sucrose. Sucrose compared to water produced robust activation in primary gustatory cortex, ventral insula, amygdala, and ventral striatum. FHP subjects displayed greater bilateral amygdala activation than FHN subjects in the low sucrose concentration (0.10 M). In secondary analyses, the right amygdala response to the 0.10 M sucrose was greatest in FHP women. When accounting for group differences in drinks per week, the family history groups remained significantly different in their right amygdala response to 0.10 M sucrose. Our findings suggest that the brain response to oral sucrose differs with a family history of alcoholism, and that this response to a mildly reinforcing primary reward might be an endophenotypic marker of alcoholism risk.

KW - Alcohol

KW - fMRI

KW - Gustatory

KW - Sweet

KW - Taste

UR - http://www.scopus.com/inward/record.url?scp=85040353162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040353162&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2017.12.019

DO - 10.1016/j.nicl.2017.12.019

M3 - Article

VL - 17

SP - 1036

EP - 1046

JO - NeuroImage: Clinical

T2 - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -