Family history of melanoma and Parkinson disease risk

X. Gao, K. C. Simon, Jiali Han, M. A. Schwarzschild, A. Ascherio

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

BACKGROUND:: Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. METHODS:: We prospectively examined associations between a family history of melanoma and PD among 157,036 men and women free of PD at baseline (1990 for men and 1982 for women) who participated in 2 ongoing US cohorts: the Health Professional Follow-up Study and the NursesÊ Health Study. Information on family history of melanoma in parents or siblings was assessed via questionnaire. Relative risks and 95% confidence intervals were estimated using Cox proportional hazards models and pooled using a fixed-effects model. RESULTS:: During 14-20 years follow-up, we identified 616 incident PD cases. A family history of melanoma in a first-degree relative was associated with a higher risk of PD (multivariate relative risk = 1.85; 95% confidence interval: 1.2, 2.8; p = 0.004), after adjusting for smoking, ethnicity, caffeine intake, and other covariates. In contrast, we did not observe significant associations between a family history of colorectal, lung, prostate, or breast cancer and PD risk. Interactions between melanoma family history and age, smoking, or caffeine intake were not significant and subgroup analyses according to these factors generated similar results. CONCLUSIONS:: Our findings support the notion that melanoma and Parkinson disease (PD) share common genetic components. The genetic determinants of melanoma could therefore be explored as susceptibility candidate genes for PD.

Original languageEnglish (US)
Pages (from-to)1286-1291
Number of pages6
JournalNeurology
Volume73
Issue number16
DOIs
StatePublished - Dec 24 2009
Externally publishedYes

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Parkinson Disease
Melanoma
Caffeine
Smoking
Confidence Intervals
Breast Diseases
Health
Proportional Hazards Models
Siblings
Lung Neoplasms
Prostatic Neoplasms
Parents
Nurses
Breast Neoplasms
Genes

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Gao, X., Simon, K. C., Han, J., Schwarzschild, M. A., & Ascherio, A. (2009). Family history of melanoma and Parkinson disease risk. Neurology, 73(16), 1286-1291. https://doi.org/10.1212/WNL.0b013e3181bd13a1

Family history of melanoma and Parkinson disease risk. / Gao, X.; Simon, K. C.; Han, Jiali; Schwarzschild, M. A.; Ascherio, A.

In: Neurology, Vol. 73, No. 16, 24.12.2009, p. 1286-1291.

Research output: Contribution to journalArticle

Gao, X, Simon, KC, Han, J, Schwarzschild, MA & Ascherio, A 2009, 'Family history of melanoma and Parkinson disease risk', Neurology, vol. 73, no. 16, pp. 1286-1291. https://doi.org/10.1212/WNL.0b013e3181bd13a1
Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Family history of melanoma and Parkinson disease risk. Neurology. 2009 Dec 24;73(16):1286-1291. https://doi.org/10.1212/WNL.0b013e3181bd13a1
Gao, X. ; Simon, K. C. ; Han, Jiali ; Schwarzschild, M. A. ; Ascherio, A. / Family history of melanoma and Parkinson disease risk. In: Neurology. 2009 ; Vol. 73, No. 16. pp. 1286-1291.
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