Fanconi anemia and the cell cycle: New perspectives on aneuploidy

Grzegorz Nalepa, D. Clapp

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Fanconi anemia (FA) is a complex heterogenic disorder of genomic instability, bone marrow failure, cancer predisposition, and congenital malformations. The FA signaling network orchestrates the DNA damage recognition and repair in interphase as well as proper execution of mitosis. Loss of FA signaling causes chromosome instability by weakening the spindle assembly checkpoint, disrupting centrosome maintenance, disturbing resolution of ultrafine anaphase bridges, and dysregulating cytokinesis. Thus, the FA genes function as guardians of genome stability throughout the cell cycle. This review discusses recent advances in diagnosis and clinical management of Fanconi anemia and presents the new insights into the origins of genomic instability in FA. These new discoveries may facilitate the development of rational therapeutic strategies for FA and for FA-deficient malignancies in the general population.

Original languageEnglish
JournalF1000Prime Reports
Volume6
DOIs
StatePublished - Apr 1 2014

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Fanconi Anemia
Aneuploidy
Cell Cycle
Genomic Instability
M Phase Cell Cycle Checkpoints
Centrosome
Chromosomal Instability
Anaphase
Cytokinesis
Interphase
Mitosis
DNA Repair
DNA Damage
Neoplasms
Bone Marrow
Maintenance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fanconi anemia and the cell cycle : New perspectives on aneuploidy. / Nalepa, Grzegorz; Clapp, D.

In: F1000Prime Reports, Vol. 6, 01.04.2014.

Research output: Contribution to journalArticle

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