Faster cholinergic rem sleep induction in euthymic patients with primary affective illness

N. Sltaram, John I. Nurnberger, Elliot S. Gershon, J. Christian Gillin

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission.

Original languageEnglish (US)
Pages (from-to)200-201
Number of pages2
JournalScience
Volume208
Issue number4440
DOIs
StatePublished - 1980
Externally publishedYes

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