Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment

Thilinie D. Bandaranayake, Onyema E. Ogbuagu, Amit Mahajan, Alexander Vortmeyer, Merceditas S. Villanueva

Research output: Contribution to journalArticle

Abstract

Cryptococcus neoformans is a ubiquitous encapsulated environmental yeast that can cause severe central nervous system disease, primarily in immune compromised hosts. In patients with AIDS, the spectrum of cryptococcal central nervous system disease includes meningitis, cystic lesions, and mass-like cryptococcomas. We report a fatal case of meningitis and cerebritis caused by C. neoformans in an AIDS patient refractory to multiple courses of liposomal amphotericin B despite immune recovery with antiretroviral therapy. This case highlights ongoing diagnostic and therapeutic challenges in the face of treatment failure for cryptococcal meningitis and reinforces the need for improved treatment approaches.

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
JournalInternational Journal of STD and AIDS
Volume29
Issue number12
DOIs
StatePublished - Oct 1 2018
Externally publishedYes

Fingerprint

Immune Reconstitution Inflammatory Syndrome
Cryptococcal Meningitis
Amphotericin B
Acquired Immunodeficiency Syndrome
Cryptococcus neoformans
Central Nervous System Diseases
Meningitis
Treatment Failure
Therapeutics
Yeasts

Keywords

  • amphotericin B
  • Cryptococcus neoformans
  • HIV
  • meningitis

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. / Bandaranayake, Thilinie D.; Ogbuagu, Onyema E.; Mahajan, Amit; Vortmeyer, Alexander; Villanueva, Merceditas S.

In: International Journal of STD and AIDS, Vol. 29, No. 12, 01.10.2018, p. 1250-1254.

Research output: Contribution to journalArticle

Bandaranayake, Thilinie D. ; Ogbuagu, Onyema E. ; Mahajan, Amit ; Vortmeyer, Alexander ; Villanueva, Merceditas S. / Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. In: International Journal of STD and AIDS. 2018 ; Vol. 29, No. 12. pp. 1250-1254.
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