Fatal stongyloides hyperinfection in heart transplantation

Hicham Ziad El Masry, Jacqueline O'Donnell

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

S stercoralis is an intestinal parasite that normally causes a chronic, low-grade, mostly asymptomatic infection. Hyperinfection syndrome and dissemination, with secondary sepsis, may occur in immunosuppressed patients, especially those on corticosteroid therapy. We present a case of fatal strongyloidiasis occurring in a patient 1 month after orthotopic heart transplantation (OHT). We assess the diagnostic challenges in these patients where pulmonary and gastrointestinal symptoms predominate as presenting clinical manifestations. We also investigate the role of screening and prophylactic anti-helmintic therapy in patients at high risk of harboring the occult intestinal infection.

Original languageEnglish
Pages (from-to)1980-1983
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume24
Issue number11
DOIs
StatePublished - Nov 2005

Fingerprint

Heart Transplantation
Strongyloidiasis
Asymptomatic Infections
Sepsis
Adrenal Cortex Hormones
Parasites
Lung
Therapeutics
Infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Fatal stongyloides hyperinfection in heart transplantation. / Ziad El Masry, Hicham; O'Donnell, Jacqueline.

In: Journal of Heart and Lung Transplantation, Vol. 24, No. 11, 11.2005, p. 1980-1983.

Research output: Contribution to journalArticle

@article{7e2b037c34b943a895b0ea8a28b706b6,
title = "Fatal stongyloides hyperinfection in heart transplantation",
abstract = "S stercoralis is an intestinal parasite that normally causes a chronic, low-grade, mostly asymptomatic infection. Hyperinfection syndrome and dissemination, with secondary sepsis, may occur in immunosuppressed patients, especially those on corticosteroid therapy. We present a case of fatal strongyloidiasis occurring in a patient 1 month after orthotopic heart transplantation (OHT). We assess the diagnostic challenges in these patients where pulmonary and gastrointestinal symptoms predominate as presenting clinical manifestations. We also investigate the role of screening and prophylactic anti-helmintic therapy in patients at high risk of harboring the occult intestinal infection.",
author = "{Ziad El Masry}, Hicham and Jacqueline O'Donnell",
year = "2005",
month = "11",
doi = "10.1016/j.healun.2005.04.005",
language = "English",
volume = "24",
pages = "1980--1983",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Fatal stongyloides hyperinfection in heart transplantation

AU - Ziad El Masry, Hicham

AU - O'Donnell, Jacqueline

PY - 2005/11

Y1 - 2005/11

N2 - S stercoralis is an intestinal parasite that normally causes a chronic, low-grade, mostly asymptomatic infection. Hyperinfection syndrome and dissemination, with secondary sepsis, may occur in immunosuppressed patients, especially those on corticosteroid therapy. We present a case of fatal strongyloidiasis occurring in a patient 1 month after orthotopic heart transplantation (OHT). We assess the diagnostic challenges in these patients where pulmonary and gastrointestinal symptoms predominate as presenting clinical manifestations. We also investigate the role of screening and prophylactic anti-helmintic therapy in patients at high risk of harboring the occult intestinal infection.

AB - S stercoralis is an intestinal parasite that normally causes a chronic, low-grade, mostly asymptomatic infection. Hyperinfection syndrome and dissemination, with secondary sepsis, may occur in immunosuppressed patients, especially those on corticosteroid therapy. We present a case of fatal strongyloidiasis occurring in a patient 1 month after orthotopic heart transplantation (OHT). We assess the diagnostic challenges in these patients where pulmonary and gastrointestinal symptoms predominate as presenting clinical manifestations. We also investigate the role of screening and prophylactic anti-helmintic therapy in patients at high risk of harboring the occult intestinal infection.

UR - http://www.scopus.com/inward/record.url?scp=27844503093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27844503093&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2005.04.005

DO - 10.1016/j.healun.2005.04.005

M3 - Article

VL - 24

SP - 1980

EP - 1983

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 11

ER -