Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis

Allon Friedman, Zhangsheng Yu, Cheryl Denski, Hector Tamez, Julia Wenger, Ravi Thadhani, Yong Li, Bruce Watkins

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Little is known about risk factors for sudden cardiac death in hemodialysis patients during the high-risk first year of dialysis. We therefore undertook to identify such risk factors in a nationally representative cohort and were able to include baseline levels of blood fatty acids, some of which influence arrhythmogenicity and sudden cardiac death risk. Design: The study cohort included 100 patients who died of sudden cardiac death during the first year of hemodialysis and 300 frequency-matched controls. Using the elastic net statistical method, numerous demographic and clinical characteristics were included with baseline total serum levels for 11 major fatty acids (model 1) and with serum phospholipid fractions of these same fatty acids (model 2). Final models included only covariates that had a non-zero coefficient. Results: In model 1, serum albumin [odds ratio (95% CI): 0.55 (0.33-0.93); p = 0.03] and total serum long-chain n-3 docosapentaenoic acid [0.70 (0.51-0.97); p = 0.03] were inversely associated with the odds of sudden cardiac death, while the total serum saturated fatty acid level had a direct association [1.01 (1.00-1.02); p = 0.03]. In model 2, serum albumin and docosapentaenoic acid remained inversely associated with sudden cardiac death in a similar manner as in model 1. Pulse pressure also had an inverse association [0.96 (0.93-1.00); p < 0.05]. Conclusions: Several factors, including blood content of docosapentaenoic acid and saturated fatty acids, were associated with the odds of sudden cardiac death during year one of hemodialysis. These results raise the possibility that dietary modification may reduce sudden death risk.

Original languageEnglish
Pages (from-to)12-18
Number of pages7
JournalAmerican Journal of Nephrology
Volume38
Issue number1
DOIs
StatePublished - Jul 2013

Fingerprint

Sudden Cardiac Death
Renal Dialysis
Fatty Acids
Serum
Serum Albumin
Diet Therapy
Sudden Death
Dialysis
Phospholipids
Cohort Studies
Odds Ratio
Demography
Blood Pressure
docosapentaenoic acid

Keywords

  • Cardiovascular disease
  • Fatty acids
  • Hemodialysis
  • Incident
  • Nutrition
  • Omega-3
  • Risk factors
  • Sudden cardiac death

ASJC Scopus subject areas

  • Nephrology

Cite this

Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. / Friedman, Allon; Yu, Zhangsheng; Denski, Cheryl; Tamez, Hector; Wenger, Julia; Thadhani, Ravi; Li, Yong; Watkins, Bruce.

In: American Journal of Nephrology, Vol. 38, No. 1, 07.2013, p. 12-18.

Research output: Contribution to journalArticle

Friedman, Allon ; Yu, Zhangsheng ; Denski, Cheryl ; Tamez, Hector ; Wenger, Julia ; Thadhani, Ravi ; Li, Yong ; Watkins, Bruce. / Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. In: American Journal of Nephrology. 2013 ; Vol. 38, No. 1. pp. 12-18.
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