FDG-PET and MRI in temporal lobe epilepsy: Relationship to febrile seizures, hippocampal sclerosis and outcome

Vicenta Salanova, Omkar Markand, R. Worth, R. Smith, H. Wellman, Gary Hutchins, H. Park, Bernardino Ghetti, B. Azzarelli

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objective - To correlate the volumetric head magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET) scan findings with the history, intracarotid amobarbital procedure, pathology, and outcome in patients with medically refractory temporal lobe epilepsy. Material and methods - Thirty-eight patients with temporal lobe epilepsy treated surgically following a comprehensive presurgical evaluation. Follow- up ranged from 12 to 44 months. Results - Volumetric MRI showed ipsilateral hippocampal atrophy in 29 (76%), and PET scan showed ipsilateral temporal hypometabolism (PET-TH) in 31 (81.5%) of patients. Eighty-three percent of those patients with hippocampal sclerosis on MRI (MRI-HS) had ipsilateral PET-TH. Sixty-six percent of patients with MRI-HS had a history of prolonged febrile convulsions or a childhood febrile illness accompanied by convulsions, and 77% of patients with MRI-HS had pathologically proven hippocampal sclerosis (HS). Ninety percent became seizure free or had rare seizures. Conclusion - FDG-PET scans and head MRIs were complementary; 95% of patients had either MRI-HS or temporal hypometabolism. MRI-HS correlated with a history of febrile seizures and pathologically demonstrated hippocampal sclerosis. Ninety-three percent of patients had focal functional deficits on the epileptogenic side. Concordance between PET temporal hypometabolism and MRI-HS correlated with better outcome.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalActa Neurologica Scandinavica
Volume97
Issue number3
StatePublished - 1998

Fingerprint

Febrile Seizures
Temporal Lobe Epilepsy
Sclerosis
Positron-Emission Tomography
Magnetic Resonance Imaging
Seizures
Head
Amobarbital
Atrophy
Fever
History
Pathology

Keywords

  • FDG-PET
  • Head MRI
  • Outcome
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

FDG-PET and MRI in temporal lobe epilepsy : Relationship to febrile seizures, hippocampal sclerosis and outcome. / Salanova, Vicenta; Markand, Omkar; Worth, R.; Smith, R.; Wellman, H.; Hutchins, Gary; Park, H.; Ghetti, Bernardino; Azzarelli, B.

In: Acta Neurologica Scandinavica, Vol. 97, No. 3, 1998, p. 146-153.

Research output: Contribution to journalArticle

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AU - Salanova, Vicenta

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AU - Worth, R.

AU - Smith, R.

AU - Wellman, H.

AU - Hutchins, Gary

AU - Park, H.

AU - Ghetti, Bernardino

AU - Azzarelli, B.

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