FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume

Jeffrey D. Wagner, Donald S. Schauwecker, Darrell Davidson, Stacie Wenck, Sin Ho Jung, Gary Hutchins

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background and Objectives: The purpose of this study is to determine the tumor volume threshold for successful positron emission tomography (PET) imaging of melanoma nodal metastases. Methods: Review of a clinical series of patients who had FDG-PET imaging of regional lymph node basins followed by lymphadenectomy. Lymph node tumor volumes were calculated from direct measurements of metastatic nodule(s) in formalin fixed specimens. PET scan interpretations were correlated with histology to determine sensitivity. Sensitivity was correlated with the aggregate lymph node tumor volume in the nodal basin and with AJCC stage group. Results: Forty-five patients with 49 pathologically positive regional nodal basins comprised the study group. Median total basin tumor volume was 28.3 mm3 (range 0.004-22,879 mm3). FDG-PET sensitivity for detection of all tumor volumes was 0.49. The observed 90% sensitivity threshold for detection of nodal metastases was ≥78 mm3. PET sensitivity was 0.14 for detection of tumor volumes <78 mm3. PET sensitivity differed by prescan AJCC stage: I - 0.0; II - 0.24; III - 0.81; IV - 1.0 (P < 0.001). Conclusions: FDG-PET reliably detects lymph node tumor deposits greater than approximately 80 mm3 volume, but sensitivity falls rapidly below this. This amount of tumor is most likely to occur in patients with AJCC stage III or IV disease.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalJournal of Surgical Oncology
Volume77
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Tumor Burden
Positron-Emission Tomography
Melanoma
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Formaldehyde
Neoplasms
Histology

Keywords

  • Fluorodeoxyglucose
  • Lymph nodes
  • Melanoma
  • Metastases
  • PET

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume. / Wagner, Jeffrey D.; Schauwecker, Donald S.; Davidson, Darrell; Wenck, Stacie; Jung, Sin Ho; Hutchins, Gary.

In: Journal of Surgical Oncology, Vol. 77, No. 4, 2001, p. 237-242.

Research output: Contribution to journalArticle

Wagner, Jeffrey D. ; Schauwecker, Donald S. ; Davidson, Darrell ; Wenck, Stacie ; Jung, Sin Ho ; Hutchins, Gary. / FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume. In: Journal of Surgical Oncology. 2001 ; Vol. 77, No. 4. pp. 237-242.
@article{12701d23049340a8b58bcde8f8949a66,
title = "FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume",
abstract = "Background and Objectives: The purpose of this study is to determine the tumor volume threshold for successful positron emission tomography (PET) imaging of melanoma nodal metastases. Methods: Review of a clinical series of patients who had FDG-PET imaging of regional lymph node basins followed by lymphadenectomy. Lymph node tumor volumes were calculated from direct measurements of metastatic nodule(s) in formalin fixed specimens. PET scan interpretations were correlated with histology to determine sensitivity. Sensitivity was correlated with the aggregate lymph node tumor volume in the nodal basin and with AJCC stage group. Results: Forty-five patients with 49 pathologically positive regional nodal basins comprised the study group. Median total basin tumor volume was 28.3 mm3 (range 0.004-22,879 mm3). FDG-PET sensitivity for detection of all tumor volumes was 0.49. The observed 90{\%} sensitivity threshold for detection of nodal metastases was ≥78 mm3. PET sensitivity was 0.14 for detection of tumor volumes <78 mm3. PET sensitivity differed by prescan AJCC stage: I - 0.0; II - 0.24; III - 0.81; IV - 1.0 (P < 0.001). Conclusions: FDG-PET reliably detects lymph node tumor deposits greater than approximately 80 mm3 volume, but sensitivity falls rapidly below this. This amount of tumor is most likely to occur in patients with AJCC stage III or IV disease.",
keywords = "Fluorodeoxyglucose, Lymph nodes, Melanoma, Metastases, PET",
author = "Wagner, {Jeffrey D.} and Schauwecker, {Donald S.} and Darrell Davidson and Stacie Wenck and Jung, {Sin Ho} and Gary Hutchins",
year = "2001",
doi = "10.1002/jso.1102",
language = "English",
volume = "77",
pages = "237--242",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - FDG-PET sensitivity for melanoma lymph node metastases is dependent on tumor volume

AU - Wagner, Jeffrey D.

AU - Schauwecker, Donald S.

AU - Davidson, Darrell

AU - Wenck, Stacie

AU - Jung, Sin Ho

AU - Hutchins, Gary

PY - 2001

Y1 - 2001

N2 - Background and Objectives: The purpose of this study is to determine the tumor volume threshold for successful positron emission tomography (PET) imaging of melanoma nodal metastases. Methods: Review of a clinical series of patients who had FDG-PET imaging of regional lymph node basins followed by lymphadenectomy. Lymph node tumor volumes were calculated from direct measurements of metastatic nodule(s) in formalin fixed specimens. PET scan interpretations were correlated with histology to determine sensitivity. Sensitivity was correlated with the aggregate lymph node tumor volume in the nodal basin and with AJCC stage group. Results: Forty-five patients with 49 pathologically positive regional nodal basins comprised the study group. Median total basin tumor volume was 28.3 mm3 (range 0.004-22,879 mm3). FDG-PET sensitivity for detection of all tumor volumes was 0.49. The observed 90% sensitivity threshold for detection of nodal metastases was ≥78 mm3. PET sensitivity was 0.14 for detection of tumor volumes <78 mm3. PET sensitivity differed by prescan AJCC stage: I - 0.0; II - 0.24; III - 0.81; IV - 1.0 (P < 0.001). Conclusions: FDG-PET reliably detects lymph node tumor deposits greater than approximately 80 mm3 volume, but sensitivity falls rapidly below this. This amount of tumor is most likely to occur in patients with AJCC stage III or IV disease.

AB - Background and Objectives: The purpose of this study is to determine the tumor volume threshold for successful positron emission tomography (PET) imaging of melanoma nodal metastases. Methods: Review of a clinical series of patients who had FDG-PET imaging of regional lymph node basins followed by lymphadenectomy. Lymph node tumor volumes were calculated from direct measurements of metastatic nodule(s) in formalin fixed specimens. PET scan interpretations were correlated with histology to determine sensitivity. Sensitivity was correlated with the aggregate lymph node tumor volume in the nodal basin and with AJCC stage group. Results: Forty-five patients with 49 pathologically positive regional nodal basins comprised the study group. Median total basin tumor volume was 28.3 mm3 (range 0.004-22,879 mm3). FDG-PET sensitivity for detection of all tumor volumes was 0.49. The observed 90% sensitivity threshold for detection of nodal metastases was ≥78 mm3. PET sensitivity was 0.14 for detection of tumor volumes <78 mm3. PET sensitivity differed by prescan AJCC stage: I - 0.0; II - 0.24; III - 0.81; IV - 1.0 (P < 0.001). Conclusions: FDG-PET reliably detects lymph node tumor deposits greater than approximately 80 mm3 volume, but sensitivity falls rapidly below this. This amount of tumor is most likely to occur in patients with AJCC stage III or IV disease.

KW - Fluorodeoxyglucose

KW - Lymph nodes

KW - Melanoma

KW - Metastases

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0034885050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034885050&partnerID=8YFLogxK

U2 - 10.1002/jso.1102

DO - 10.1002/jso.1102

M3 - Article

C2 - 11473371

AN - SCOPUS:0034885050

VL - 77

SP - 237

EP - 242

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 4

ER -