Fear-potentiated startle elevates catecholamine levels in the dorsomedial hypothalamus of rats

Anantha Shekhar, J. S. Katner, W. P. Rusche, T. J. Sajdyk, J. R. Simon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The norepinephrine (NE), dopamine (DA), and serotonin (5-HT) systems are thought to be important in the development of anxiety and stress. The dorsomedial hypothalamus (DMH) of rats has been implicated in the regulation of physiological and behavioral responses associated with fear and anxiety. In order to elucidate the interactions between the monoamine systems and the DMH, we studied the effects of subjecting rats to the fear-potentiated startle test, a commonly used test of anxiety in rats, on the NE, DA, and 5-HT levels in the DMH. Rats in the potentiated startle test, but not those exposed to just foot shocks or acoustic startle, showed significantly higher levels of NE and DA in the DMH compared to cage controls. In contrast, foot shocks significantly elevated the 5-HT levels in the DMH.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume48
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Hypothalamus
Fear
Catecholamines
Rats
Serotonin
Dopamine
Norepinephrine
Anxiety
Foot
Shock
Acoustics

Keywords

  • Anxiety
  • Conditioned fear
  • Dopamine
  • Norepinephrine
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Fear-potentiated startle elevates catecholamine levels in the dorsomedial hypothalamus of rats. / Shekhar, Anantha; Katner, J. S.; Rusche, W. P.; Sajdyk, T. J.; Simon, J. R.

In: Pharmacology Biochemistry and Behavior, Vol. 48, No. 2, 1994, p. 525-529.

Research output: Contribution to journalArticle

Shekhar, Anantha ; Katner, J. S. ; Rusche, W. P. ; Sajdyk, T. J. ; Simon, J. R. / Fear-potentiated startle elevates catecholamine levels in the dorsomedial hypothalamus of rats. In: Pharmacology Biochemistry and Behavior. 1994 ; Vol. 48, No. 2. pp. 525-529.
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