Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy: Study in a canine model

David Y. Chan, Leonidas Koniaris, Carolyn Magee, Meg Ferrell, Stephen Solomon, Benjamin R. Lee, James H. Anderson, Donald O. Smith, Joseph Czapski, Theodore Deweese, Michael A. Choti, Louis R. Kavoussi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Purpose: A miniature photon radiosurgery system (PRS) has been described as an alternative to surgical resection and external-beam radiation for tumors and may now offer an alternative for ablation of renal lesions. We evaluated the feasibility of ablation by PRS in a normal parenchyma canine model. Materials and Methods: Twelve mongrel dogs were used in this survival study. In the left and right kidneys of each animal, a peripheral lesion and central-hilar lesion, respectively, were induced with PRS. The probes were placed in the renal parenchyma, and local radiation of 15 Gy at a radius of 1.3 cm was delivered over 10 minutes. Serum electrolytes were measured serially. Computed tomography scans were obtained, and the animals were sacrificed for pathologic correlation. In a separate study, the liver received three additional treatments of 10 to 20 minutes of radiation. Results: Eleven dogs survived this 6-month study and were sacrificed as scheduled. One animal expired after 2 weeks from radiation-induced fulminant hepatic failure with normal renal function. No other complications were observed. The average lesion size was 2.5 cm in diameter. Histologic analysis confirmed coagulative necrosis with sharp demarcation from the surrounding parenchyma. Conclusion: Preliminary studies demonstrate the feasibility of PRS ablation of the renal parenchyma. Further tumor model testing will be important to determine the ultimate efficacy of local photon radiation energy.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Endourology
Volume14
Issue number2
StatePublished - 2000
Externally publishedYes

Fingerprint

Photons
Radiosurgery
Canidae
Radiation
Kidney
Dogs
Radiation Dosage
Acute Liver Failure
Feasibility Studies
Electrolytes
Neoplasms
Necrosis
Tomography
Liver
Serum
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Chan, D. Y., Koniaris, L., Magee, C., Ferrell, M., Solomon, S., Lee, B. R., ... Kavoussi, L. R. (2000). Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy: Study in a canine model. Journal of Endourology, 14(2), 111-116.

Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy : Study in a canine model. / Chan, David Y.; Koniaris, Leonidas; Magee, Carolyn; Ferrell, Meg; Solomon, Stephen; Lee, Benjamin R.; Anderson, James H.; Smith, Donald O.; Czapski, Joseph; Deweese, Theodore; Choti, Michael A.; Kavoussi, Louis R.

In: Journal of Endourology, Vol. 14, No. 2, 2000, p. 111-116.

Research output: Contribution to journalArticle

Chan, DY, Koniaris, L, Magee, C, Ferrell, M, Solomon, S, Lee, BR, Anderson, JH, Smith, DO, Czapski, J, Deweese, T, Choti, MA & Kavoussi, LR 2000, 'Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy: Study in a canine model', Journal of Endourology, vol. 14, no. 2, pp. 111-116.
Chan, David Y. ; Koniaris, Leonidas ; Magee, Carolyn ; Ferrell, Meg ; Solomon, Stephen ; Lee, Benjamin R. ; Anderson, James H. ; Smith, Donald O. ; Czapski, Joseph ; Deweese, Theodore ; Choti, Michael A. ; Kavoussi, Louis R. / Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy : Study in a canine model. In: Journal of Endourology. 2000 ; Vol. 14, No. 2. pp. 111-116.
@article{be39df67a4094f458c1efbd00496e8a4,
title = "Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy: Study in a canine model",
abstract = "Background and Purpose: A miniature photon radiosurgery system (PRS) has been described as an alternative to surgical resection and external-beam radiation for tumors and may now offer an alternative for ablation of renal lesions. We evaluated the feasibility of ablation by PRS in a normal parenchyma canine model. Materials and Methods: Twelve mongrel dogs were used in this survival study. In the left and right kidneys of each animal, a peripheral lesion and central-hilar lesion, respectively, were induced with PRS. The probes were placed in the renal parenchyma, and local radiation of 15 Gy at a radius of 1.3 cm was delivered over 10 minutes. Serum electrolytes were measured serially. Computed tomography scans were obtained, and the animals were sacrificed for pathologic correlation. In a separate study, the liver received three additional treatments of 10 to 20 minutes of radiation. Results: Eleven dogs survived this 6-month study and were sacrificed as scheduled. One animal expired after 2 weeks from radiation-induced fulminant hepatic failure with normal renal function. No other complications were observed. The average lesion size was 2.5 cm in diameter. Histologic analysis confirmed coagulative necrosis with sharp demarcation from the surrounding parenchyma. Conclusion: Preliminary studies demonstrate the feasibility of PRS ablation of the renal parenchyma. Further tumor model testing will be important to determine the ultimate efficacy of local photon radiation energy.",
author = "Chan, {David Y.} and Leonidas Koniaris and Carolyn Magee and Meg Ferrell and Stephen Solomon and Lee, {Benjamin R.} and Anderson, {James H.} and Smith, {Donald O.} and Joseph Czapski and Theodore Deweese and Choti, {Michael A.} and Kavoussi, {Louis R.}",
year = "2000",
language = "English (US)",
volume = "14",
pages = "111--116",
journal = "Journal of Endourology",
issn = "0892-7790",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

TY - JOUR

T1 - Feasibility of ablating normal renal parenchyma by interstitial photon radiation energy

T2 - Study in a canine model

AU - Chan, David Y.

AU - Koniaris, Leonidas

AU - Magee, Carolyn

AU - Ferrell, Meg

AU - Solomon, Stephen

AU - Lee, Benjamin R.

AU - Anderson, James H.

AU - Smith, Donald O.

AU - Czapski, Joseph

AU - Deweese, Theodore

AU - Choti, Michael A.

AU - Kavoussi, Louis R.

PY - 2000

Y1 - 2000

N2 - Background and Purpose: A miniature photon radiosurgery system (PRS) has been described as an alternative to surgical resection and external-beam radiation for tumors and may now offer an alternative for ablation of renal lesions. We evaluated the feasibility of ablation by PRS in a normal parenchyma canine model. Materials and Methods: Twelve mongrel dogs were used in this survival study. In the left and right kidneys of each animal, a peripheral lesion and central-hilar lesion, respectively, were induced with PRS. The probes were placed in the renal parenchyma, and local radiation of 15 Gy at a radius of 1.3 cm was delivered over 10 minutes. Serum electrolytes were measured serially. Computed tomography scans were obtained, and the animals were sacrificed for pathologic correlation. In a separate study, the liver received three additional treatments of 10 to 20 minutes of radiation. Results: Eleven dogs survived this 6-month study and were sacrificed as scheduled. One animal expired after 2 weeks from radiation-induced fulminant hepatic failure with normal renal function. No other complications were observed. The average lesion size was 2.5 cm in diameter. Histologic analysis confirmed coagulative necrosis with sharp demarcation from the surrounding parenchyma. Conclusion: Preliminary studies demonstrate the feasibility of PRS ablation of the renal parenchyma. Further tumor model testing will be important to determine the ultimate efficacy of local photon radiation energy.

AB - Background and Purpose: A miniature photon radiosurgery system (PRS) has been described as an alternative to surgical resection and external-beam radiation for tumors and may now offer an alternative for ablation of renal lesions. We evaluated the feasibility of ablation by PRS in a normal parenchyma canine model. Materials and Methods: Twelve mongrel dogs were used in this survival study. In the left and right kidneys of each animal, a peripheral lesion and central-hilar lesion, respectively, were induced with PRS. The probes were placed in the renal parenchyma, and local radiation of 15 Gy at a radius of 1.3 cm was delivered over 10 minutes. Serum electrolytes were measured serially. Computed tomography scans were obtained, and the animals were sacrificed for pathologic correlation. In a separate study, the liver received three additional treatments of 10 to 20 minutes of radiation. Results: Eleven dogs survived this 6-month study and were sacrificed as scheduled. One animal expired after 2 weeks from radiation-induced fulminant hepatic failure with normal renal function. No other complications were observed. The average lesion size was 2.5 cm in diameter. Histologic analysis confirmed coagulative necrosis with sharp demarcation from the surrounding parenchyma. Conclusion: Preliminary studies demonstrate the feasibility of PRS ablation of the renal parenchyma. Further tumor model testing will be important to determine the ultimate efficacy of local photon radiation energy.

UR - http://www.scopus.com/inward/record.url?scp=17144436556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144436556&partnerID=8YFLogxK

M3 - Article

C2 - 10772501

AN - SCOPUS:17144436556

VL - 14

SP - 111

EP - 116

JO - Journal of Endourology

JF - Journal of Endourology

SN - 0892-7790

IS - 2

ER -