Feasibility of combination allogeneic stem cell therapy for spinal cord injury: A case report

Thomas E. Ichim, Fabio Solano, Fabian Lara, Eugenia Paris, Federico Ugalde, Jorge Paz Rodriguez, Boris Minev, Vladimir Bogin, Famela Ramos, Erik J. Woods, Michael P. Murphy, Amit N. Patel, Robert J. Harman, Neil H. Riordan

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI.

Original languageEnglish (US)
Article number30
JournalInternational Archives of Medicine
Volume3
Issue number1
DOIs
StatePublished - Nov 15 2010

ASJC Scopus subject areas

  • Medicine(all)

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    Ichim, T. E., Solano, F., Lara, F., Paris, E., Ugalde, F., Rodriguez, J. P., Minev, B., Bogin, V., Ramos, F., Woods, E. J., Murphy, M. P., Patel, A. N., Harman, R. J., & Riordan, N. H. (2010). Feasibility of combination allogeneic stem cell therapy for spinal cord injury: A case report. International Archives of Medicine, 3(1), [30]. https://doi.org/10.1186/1755-7682-3-30