Feasibility Study of Erythrocyte Long-Chain Omega-3 Polyunsaturated Fatty Acid Content and Mortality Risk in Hemodialysis Patients

Allon Friedman, Chandan Saha, Bruce A. Watkins

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: Long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are increasingly believed to be cardioprotective. We tested the hypothesis that erythrocyte n-3 PUFA levels, as measured by the omega-3 index (O3I), are inversely related to mortality in hemodialysis patients. Design and Study Population: This was a retrospective study of 93 prevalent urban American hemodialysis patients with baseline n-3 PUFA blood levels. Main Outcome Measure: The mortality rate was measured over a median period of 755 days. Results: The median omega-3 index was 4.69 mean weight %. During follow-up, 19 patients died, and 8 underwent renal transplantation. The probability of survival was significantly greater in patients with an O3I above the median (P = .025). Univariate analyses found that increasing age and a higher Charlson Comorbidity Index were associated with reduced survival, whereas a higher O3I and black race were linked with greater survival. In a multivariate model, only the Charlson Comorbidity Index score clearly predicted mortality (hazard ratio, 1.31; 95% confidence interval, 1.06 to 1.62), though a protective trend was observed with an O3I above the median (hazard ratio, 2.48; 95% confidence interval, 0.88 to 6.95). Conclusion: Though this modest-sized study did not find a statistically significant relationship between erythrocyte n-3 PUFA levels and mortality, an inverse association was suggested. The existence of such a relationship will need to be confirmed in cohorts with greater statistical power.

Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalJournal of Renal Nutrition
Volume18
Issue number6
DOIs
StatePublished - Nov 2008

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Omega-3 Fatty Acids
Feasibility Studies
Unsaturated Fatty Acids
Renal Dialysis
Erythrocytes
Mortality
Survival
Comorbidity
Confidence Intervals
Kidney Transplantation
Retrospective Studies
Outcome Assessment (Health Care)
Weights and Measures
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

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title = "Feasibility Study of Erythrocyte Long-Chain Omega-3 Polyunsaturated Fatty Acid Content and Mortality Risk in Hemodialysis Patients",
abstract = "Objective: Long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are increasingly believed to be cardioprotective. We tested the hypothesis that erythrocyte n-3 PUFA levels, as measured by the omega-3 index (O3I), are inversely related to mortality in hemodialysis patients. Design and Study Population: This was a retrospective study of 93 prevalent urban American hemodialysis patients with baseline n-3 PUFA blood levels. Main Outcome Measure: The mortality rate was measured over a median period of 755 days. Results: The median omega-3 index was 4.69 mean weight {\%}. During follow-up, 19 patients died, and 8 underwent renal transplantation. The probability of survival was significantly greater in patients with an O3I above the median (P = .025). Univariate analyses found that increasing age and a higher Charlson Comorbidity Index were associated with reduced survival, whereas a higher O3I and black race were linked with greater survival. In a multivariate model, only the Charlson Comorbidity Index score clearly predicted mortality (hazard ratio, 1.31; 95{\%} confidence interval, 1.06 to 1.62), though a protective trend was observed with an O3I above the median (hazard ratio, 2.48; 95{\%} confidence interval, 0.88 to 6.95). Conclusion: Though this modest-sized study did not find a statistically significant relationship between erythrocyte n-3 PUFA levels and mortality, an inverse association was suggested. The existence of such a relationship will need to be confirmed in cohorts with greater statistical power.",
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AU - Saha, Chandan

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N2 - Objective: Long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are increasingly believed to be cardioprotective. We tested the hypothesis that erythrocyte n-3 PUFA levels, as measured by the omega-3 index (O3I), are inversely related to mortality in hemodialysis patients. Design and Study Population: This was a retrospective study of 93 prevalent urban American hemodialysis patients with baseline n-3 PUFA blood levels. Main Outcome Measure: The mortality rate was measured over a median period of 755 days. Results: The median omega-3 index was 4.69 mean weight %. During follow-up, 19 patients died, and 8 underwent renal transplantation. The probability of survival was significantly greater in patients with an O3I above the median (P = .025). Univariate analyses found that increasing age and a higher Charlson Comorbidity Index were associated with reduced survival, whereas a higher O3I and black race were linked with greater survival. In a multivariate model, only the Charlson Comorbidity Index score clearly predicted mortality (hazard ratio, 1.31; 95% confidence interval, 1.06 to 1.62), though a protective trend was observed with an O3I above the median (hazard ratio, 2.48; 95% confidence interval, 0.88 to 6.95). Conclusion: Though this modest-sized study did not find a statistically significant relationship between erythrocyte n-3 PUFA levels and mortality, an inverse association was suggested. The existence of such a relationship will need to be confirmed in cohorts with greater statistical power.

AB - Objective: Long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are increasingly believed to be cardioprotective. We tested the hypothesis that erythrocyte n-3 PUFA levels, as measured by the omega-3 index (O3I), are inversely related to mortality in hemodialysis patients. Design and Study Population: This was a retrospective study of 93 prevalent urban American hemodialysis patients with baseline n-3 PUFA blood levels. Main Outcome Measure: The mortality rate was measured over a median period of 755 days. Results: The median omega-3 index was 4.69 mean weight %. During follow-up, 19 patients died, and 8 underwent renal transplantation. The probability of survival was significantly greater in patients with an O3I above the median (P = .025). Univariate analyses found that increasing age and a higher Charlson Comorbidity Index were associated with reduced survival, whereas a higher O3I and black race were linked with greater survival. In a multivariate model, only the Charlson Comorbidity Index score clearly predicted mortality (hazard ratio, 1.31; 95% confidence interval, 1.06 to 1.62), though a protective trend was observed with an O3I above the median (hazard ratio, 2.48; 95% confidence interval, 0.88 to 6.95). Conclusion: Though this modest-sized study did not find a statistically significant relationship between erythrocyte n-3 PUFA levels and mortality, an inverse association was suggested. The existence of such a relationship will need to be confirmed in cohorts with greater statistical power.

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