Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction

S. Keisin Wang, Gary W. Lemmon, Alok K. Gupta, Michael C. Dalsing, Alan P. Sawchuk, Raghu L. Motaganahalli, Michael P. Murphy, Andres Fajardo

Research output: Contribution to journalArticle

2 Scopus citations


Objective: Acute kidney injury (AKI) is a common physiologic complication after fenestrated endovascular aneurysm repair (FEVAR). This investigation was initiated to determine the unknown impact of post-FEVAR AKI on long-term renal function after index hospital discharge. Methods: A retrospective review was performed of an institutional FEVAR database capturing preoperative, intraoperative, and postoperative variables related to the implantation of consecutive Zenith Fenestrated endografts (ZFEN; Cook Medical, Bloomington, Ind) between October 2012 and April 2018. AKI in this study was bimodally defined as qualification by either Risk, Injury, Failure, Loss of kidney function, and End-stage (RIFLE) criteria or a postoperative serum creatinine (sCr) concentration increase of 0.5 mg/dL from baseline. Glomerular filtration rate (GFR) was calculated using the validated Modification of Diet in Renal Disease (MDRD) study equation. Results: During the study period, 120 FEVARs were performed at our institution. Twenty-four (20%) patients exhibited postoperative AKI by our established definitions. Two in-hospital deaths occurred in the AKI cohort compared with none in the remaining FEVARs (P = .04). Four (16.7%) AKI patients required perioperative (<30-day) renal replacement therapy, three of whom were successfully weaned before discharge. FEVARs uncomplicated by AKI exhibited no differences in sCr concentration from baseline to 1-month, 6-month, 1-year, and 2-year follow-up (mean, 1.8 ± 1.4 years). In contrast, patients exhibiting AKI experienced an sCr concentration increase of 57.1% (P = .01) at 1 month after the procedure. This elevation decreased to 14.3% (P = .35) at 6 months after the procedure and was maintained at baseline values at 1- and 2-year office visits (follow-up, 1.3 ± 1.5 years). A similar pattern of gradual recovery during follow-up was also observed with respect to calculated GFR. Conclusions: AKI is common after FEVAR but rarely results in permanent renal dysfunction as both sCr concentration and GFR return to baseline by 6 months after the procedure.

Original languageEnglish (US)
Pages (from-to)1679-1684
Number of pages6
JournalJournal of vascular surgery
Issue number6
StatePublished - Jun 2019


  • Acute kidney injury (AKI)
  • Chronic renal disease
  • Fenestrated endovascular aneurysm repair (FEVAR)
  • Hemodialysis
  • Renal outcomes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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