Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals

Andrea G. Gillman, Joseph K. Leffel, Ann Kosobud, William Timberlake

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Administration of several drugs of abuse on a 24-h schedule has been shown to entrain both pre-drug (anticipatory) and post-drug (evoked) circadian activity episodes that persist for several days when the drug is withheld. The present study tested the entrainment effects of fentanyl, an opioid agonist with a noted abuse liability, and haloperidol, an anti-psychotic dopamine antagonist without apparent abuse liability. Adult female Sprague-Dawley rats housed under constant light in cages with attached running wheels received repeated low, medium, or high doses of either fentanyl or haloperidol on a 24-h administration schedule followed by a 31-h schedule (Experiment 1) or solely on a 31-h schedule (Experiment 2). The results showed that all three doses of fentanyl entrained both pre-drug and post-drug episodes of wheel running when administered every 24 h, and the combined pre- and post-fentanyl activity episodes persisted for at least 3 days when the drug was withheld during test days. On the 31-h schedule, fentanyl produced an "ensuing" activity episode approximately 24 h post-administration, but failed to produce an anticipatory episode 29-31 h post-administration. In contrast, haloperidol injections failed to produce both pre-drug episodes on the 24-h schedule and circadian ensuing episodes on the 31-h schedule, and post-haloperidol suppression of activity appeared to mask the free-running activity rhythm. Taken together, these results provide additional evidence that drugs of abuse share a common ability to entrain circadian activity episodes.

Original languageEnglish
Pages (from-to)102-114
Number of pages13
JournalBehavioural Brain Research
Volume205
Issue number1
DOIs
StatePublished - Dec 14 2009

Fingerprint

Fentanyl
Haloperidol
Appointments and Schedules
Pharmaceutical Preparations
Running
Street Drugs
Dopamine Antagonists
Masks
Opioid Analgesics
Sprague Dawley Rats
Light
Injections

Keywords

  • Circadian rhythms
  • Drug abuse
  • Drug addiction
  • Drug anticipation
  • Ensuing activity
  • Fentanyl
  • Haloperidol
  • Locomotor entrainment
  • Wheel running

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals. / Gillman, Andrea G.; Leffel, Joseph K.; Kosobud, Ann; Timberlake, William.

In: Behavioural Brain Research, Vol. 205, No. 1, 14.12.2009, p. 102-114.

Research output: Contribution to journalArticle

@article{3bc82d0eda374c20bd4c10d9dc0fa42b,
title = "Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals",
abstract = "Administration of several drugs of abuse on a 24-h schedule has been shown to entrain both pre-drug (anticipatory) and post-drug (evoked) circadian activity episodes that persist for several days when the drug is withheld. The present study tested the entrainment effects of fentanyl, an opioid agonist with a noted abuse liability, and haloperidol, an anti-psychotic dopamine antagonist without apparent abuse liability. Adult female Sprague-Dawley rats housed under constant light in cages with attached running wheels received repeated low, medium, or high doses of either fentanyl or haloperidol on a 24-h administration schedule followed by a 31-h schedule (Experiment 1) or solely on a 31-h schedule (Experiment 2). The results showed that all three doses of fentanyl entrained both pre-drug and post-drug episodes of wheel running when administered every 24 h, and the combined pre- and post-fentanyl activity episodes persisted for at least 3 days when the drug was withheld during test days. On the 31-h schedule, fentanyl produced an {"}ensuing{"} activity episode approximately 24 h post-administration, but failed to produce an anticipatory episode 29-31 h post-administration. In contrast, haloperidol injections failed to produce both pre-drug episodes on the 24-h schedule and circadian ensuing episodes on the 31-h schedule, and post-haloperidol suppression of activity appeared to mask the free-running activity rhythm. Taken together, these results provide additional evidence that drugs of abuse share a common ability to entrain circadian activity episodes.",
keywords = "Circadian rhythms, Drug abuse, Drug addiction, Drug anticipation, Ensuing activity, Fentanyl, Haloperidol, Locomotor entrainment, Wheel running",
author = "Gillman, {Andrea G.} and Leffel, {Joseph K.} and Ann Kosobud and William Timberlake",
year = "2009",
month = "12",
day = "14",
doi = "10.1016/j.bbr.2009.07.002",
language = "English",
volume = "205",
pages = "102--114",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Fentanyl, but not haloperidol, entrains persisting circadian activity episodes when administered at 24- and 31-h intervals

AU - Gillman, Andrea G.

AU - Leffel, Joseph K.

AU - Kosobud, Ann

AU - Timberlake, William

PY - 2009/12/14

Y1 - 2009/12/14

N2 - Administration of several drugs of abuse on a 24-h schedule has been shown to entrain both pre-drug (anticipatory) and post-drug (evoked) circadian activity episodes that persist for several days when the drug is withheld. The present study tested the entrainment effects of fentanyl, an opioid agonist with a noted abuse liability, and haloperidol, an anti-psychotic dopamine antagonist without apparent abuse liability. Adult female Sprague-Dawley rats housed under constant light in cages with attached running wheels received repeated low, medium, or high doses of either fentanyl or haloperidol on a 24-h administration schedule followed by a 31-h schedule (Experiment 1) or solely on a 31-h schedule (Experiment 2). The results showed that all three doses of fentanyl entrained both pre-drug and post-drug episodes of wheel running when administered every 24 h, and the combined pre- and post-fentanyl activity episodes persisted for at least 3 days when the drug was withheld during test days. On the 31-h schedule, fentanyl produced an "ensuing" activity episode approximately 24 h post-administration, but failed to produce an anticipatory episode 29-31 h post-administration. In contrast, haloperidol injections failed to produce both pre-drug episodes on the 24-h schedule and circadian ensuing episodes on the 31-h schedule, and post-haloperidol suppression of activity appeared to mask the free-running activity rhythm. Taken together, these results provide additional evidence that drugs of abuse share a common ability to entrain circadian activity episodes.

AB - Administration of several drugs of abuse on a 24-h schedule has been shown to entrain both pre-drug (anticipatory) and post-drug (evoked) circadian activity episodes that persist for several days when the drug is withheld. The present study tested the entrainment effects of fentanyl, an opioid agonist with a noted abuse liability, and haloperidol, an anti-psychotic dopamine antagonist without apparent abuse liability. Adult female Sprague-Dawley rats housed under constant light in cages with attached running wheels received repeated low, medium, or high doses of either fentanyl or haloperidol on a 24-h administration schedule followed by a 31-h schedule (Experiment 1) or solely on a 31-h schedule (Experiment 2). The results showed that all three doses of fentanyl entrained both pre-drug and post-drug episodes of wheel running when administered every 24 h, and the combined pre- and post-fentanyl activity episodes persisted for at least 3 days when the drug was withheld during test days. On the 31-h schedule, fentanyl produced an "ensuing" activity episode approximately 24 h post-administration, but failed to produce an anticipatory episode 29-31 h post-administration. In contrast, haloperidol injections failed to produce both pre-drug episodes on the 24-h schedule and circadian ensuing episodes on the 31-h schedule, and post-haloperidol suppression of activity appeared to mask the free-running activity rhythm. Taken together, these results provide additional evidence that drugs of abuse share a common ability to entrain circadian activity episodes.

KW - Circadian rhythms

KW - Drug abuse

KW - Drug addiction

KW - Drug anticipation

KW - Ensuing activity

KW - Fentanyl

KW - Haloperidol

KW - Locomotor entrainment

KW - Wheel running

UR - http://www.scopus.com/inward/record.url?scp=70349269067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349269067&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2009.07.002

DO - 10.1016/j.bbr.2009.07.002

M3 - Article

C2 - 19595707

AN - SCOPUS:70349269067

VL - 205

SP - 102

EP - 114

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -