Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations

Committee on Bioethics, Section on Hematology/Oncology, Section on Surgery

Research output: Contribution to journalReview article

Abstract

Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.

Original languageEnglish (US)
Article numbere20193994
JournalPediatrics
Volume145
Issue number3
DOIs
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations'. Together they form a unique fingerprint.

  • Cite this

    Committee on Bioethics, Section on Hematology/Oncology, & Section on Surgery (2020). Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations. Pediatrics, 145(3), [e20193994]. https://doi.org/10.1542/peds.2019-3994