Fetal alcohol spectrum disorder (FASD) associated neural defects: Complex mechanisms and potential therapeutic targets

Pooja Muralidharan, Swapnalee Sarmah, Feng Zhou, James A. Marrs

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Fetal alcohol spectrum disorder (FASD), caused by prenatal alcohol exposure, can result in craniofacial dysmorphism, cognitive impairment, sensory and motor disabilities among other defects. FASD incidences are as high as 2% to 5 % children born in the US, and prevalence is higher in low socioeconomic populations. Despite various mechanisms being proposed to explain the etiology of FASD, the molecular targets of ethanol toxicity during development are unknown. Proposed mechanisms include cell death, cell signaling defects and gene expression changes. More recently, the involvement of several other molecular pathways was explored, including non-coding RNA, epigenetic changes and specific vitamin deficiencies. These various pathways may interact, producing a wide spectrum of consequences. Detailed understanding of these various pathways and their interactions will facilitate the therapeutic target identification, leading to new clinical intervention, which may reduce the incidence and severity of these highly prevalent preventable birth defects. This review discusses manifestations of alcohol exposure on the developing central nervous system, including the neural crest cells and sensory neural placodes, focusing on molecular neurodevelopmental pathways as possible therapeutic targets for prevention or protection.

Original languageEnglish (US)
Pages (from-to)964-991
Number of pages28
JournalBrain Sciences
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2013

Fingerprint

Fetal Alcohol Spectrum Disorders
Alcohols
Avitaminosis
Untranslated RNA
Neural Crest
Incidence
Epigenomics
Cell Death
Ethanol
Therapeutics
Central Nervous System
Gene Expression
Population

Keywords

  • Central nervous system
  • Cranial neural crest cells
  • Ethanol
  • Fetal alcohol spectrum disorder
  • Fetal alcohol syndrome
  • Vitamin deficiency

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fetal alcohol spectrum disorder (FASD) associated neural defects : Complex mechanisms and potential therapeutic targets. / Muralidharan, Pooja; Sarmah, Swapnalee; Zhou, Feng; Marrs, James A.

In: Brain Sciences, Vol. 3, No. 2, 01.01.2013, p. 964-991.

Research output: Contribution to journalArticle

Muralidharan, Pooja ; Sarmah, Swapnalee ; Zhou, Feng ; Marrs, James A. / Fetal alcohol spectrum disorder (FASD) associated neural defects : Complex mechanisms and potential therapeutic targets. In: Brain Sciences. 2013 ; Vol. 3, No. 2. pp. 964-991.
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