Fetal brain disruption sequence

Cynthia A. Moore, David D. Weaver, Marilyn J. Bull

Research output: Contribution to journalArticle

31 Scopus citations


The fetal brain disruption sequence is a recognizable pattern of defects that includes moderate to profound microcephaly, overlapping sutures, occipital bone prominence, and scalp rugae. The condition is postulated to arise from partial brain disruption during the second or third trimester with subsequent fetal skull collapse resulting from decreased intracranial hydrostatic pressure. Proposed causes include prenatal viral or parasitic infections and vascular disruptions. We report seven infants with the fetal brain disruption sequence. Two of these patients died. A changing phenotype with time was seen in three. Recognition of this phenotype is critical because the condition has a uniformly poor prognosis for infants but the recurrence risk in future pregnancies is low.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalThe Journal of pediatrics
Issue number3
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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