Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

Emily K. Blue, Kimberly Ballman, Frances Boyle, Eunjin Oh, Tatsuyoshi Kono, Sara Quinney, Debbie C. Thurmond, Carmella Evans-Molina, Laura Haneline

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background:Children exposed to gestational diabetes mellitus (GDM) during pregnancy are at increased risk of obesity, diabetes, and hypertension. Our goal was to identify metabolic and hematopoietic alterations after intrauterine exposure to maternal hyperglycemia that may contribute to the pathogenesis of chronic morbidities.Methods:Streptozotocin treatment induced maternal hyperglycemia during the last third of gestation in rat dams. Offspring of control mothers (OCM) and diabetic mothers (ODM) were evaluated for weight, glucose tolerance, insulin tolerance, and hematopoiesis defects. The effects of aging were examined in normal and high-fat diet (HFD)-fed young (8-wk-old) and aged (11-mo-old) OCM and ODM rats.Results:Young adult ODM males on a normal diet, but not females, displayed improved glucose tolerance due to increased insulin levels. Aged ODM males and females gained more weight than OCM on a HFD and had worse glucose tolerance. Aged ODM males fed a HFD were also neutrophilic. Increases in bone marrow cellularity and myeloid progenitors preceded neutrophilia in ODM males fed a HFD.Conclusion:When combined with other risk factors like HFD and aging, changes in glucose metabolism and hematopoiesis may contribute to the increased risk of obesity, type 2 diabetes, and hypertension observed in children of GDM mothers.

Original languageEnglish
Pages (from-to)316-325
Number of pages10
JournalPediatric Research
Volume77
Issue number2
DOIs
StatePublished - Feb 11 2015

Fingerprint

Hematopoiesis
High Fat Diet
Hyperglycemia
Mothers
Glucose
Gestational Diabetes
Obesity
Insulin
Hypertension
Maternal Exposure
Weights and Measures
Pregnancy
Streptozocin
Type 2 Diabetes Mellitus
Young Adult
Bone Marrow
Diet
Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats. / Blue, Emily K.; Ballman, Kimberly; Boyle, Frances; Oh, Eunjin; Kono, Tatsuyoshi; Quinney, Sara; Thurmond, Debbie C.; Evans-Molina, Carmella; Haneline, Laura.

In: Pediatric Research, Vol. 77, No. 2, 11.02.2015, p. 316-325.

Research output: Contribution to journalArticle

@article{f20417efcddd4c77b2b156a1702cbbef,
title = "Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats",
abstract = "Background:Children exposed to gestational diabetes mellitus (GDM) during pregnancy are at increased risk of obesity, diabetes, and hypertension. Our goal was to identify metabolic and hematopoietic alterations after intrauterine exposure to maternal hyperglycemia that may contribute to the pathogenesis of chronic morbidities.Methods:Streptozotocin treatment induced maternal hyperglycemia during the last third of gestation in rat dams. Offspring of control mothers (OCM) and diabetic mothers (ODM) were evaluated for weight, glucose tolerance, insulin tolerance, and hematopoiesis defects. The effects of aging were examined in normal and high-fat diet (HFD)-fed young (8-wk-old) and aged (11-mo-old) OCM and ODM rats.Results:Young adult ODM males on a normal diet, but not females, displayed improved glucose tolerance due to increased insulin levels. Aged ODM males and females gained more weight than OCM on a HFD and had worse glucose tolerance. Aged ODM males fed a HFD were also neutrophilic. Increases in bone marrow cellularity and myeloid progenitors preceded neutrophilia in ODM males fed a HFD.Conclusion:When combined with other risk factors like HFD and aging, changes in glucose metabolism and hematopoiesis may contribute to the increased risk of obesity, type 2 diabetes, and hypertension observed in children of GDM mothers.",
author = "Blue, {Emily K.} and Kimberly Ballman and Frances Boyle and Eunjin Oh and Tatsuyoshi Kono and Sara Quinney and Thurmond, {Debbie C.} and Carmella Evans-Molina and Laura Haneline",
year = "2015",
month = "2",
day = "11",
doi = "10.1038/pr.2014.185",
language = "English",
volume = "77",
pages = "316--325",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

AU - Blue, Emily K.

AU - Ballman, Kimberly

AU - Boyle, Frances

AU - Oh, Eunjin

AU - Kono, Tatsuyoshi

AU - Quinney, Sara

AU - Thurmond, Debbie C.

AU - Evans-Molina, Carmella

AU - Haneline, Laura

PY - 2015/2/11

Y1 - 2015/2/11

N2 - Background:Children exposed to gestational diabetes mellitus (GDM) during pregnancy are at increased risk of obesity, diabetes, and hypertension. Our goal was to identify metabolic and hematopoietic alterations after intrauterine exposure to maternal hyperglycemia that may contribute to the pathogenesis of chronic morbidities.Methods:Streptozotocin treatment induced maternal hyperglycemia during the last third of gestation in rat dams. Offspring of control mothers (OCM) and diabetic mothers (ODM) were evaluated for weight, glucose tolerance, insulin tolerance, and hematopoiesis defects. The effects of aging were examined in normal and high-fat diet (HFD)-fed young (8-wk-old) and aged (11-mo-old) OCM and ODM rats.Results:Young adult ODM males on a normal diet, but not females, displayed improved glucose tolerance due to increased insulin levels. Aged ODM males and females gained more weight than OCM on a HFD and had worse glucose tolerance. Aged ODM males fed a HFD were also neutrophilic. Increases in bone marrow cellularity and myeloid progenitors preceded neutrophilia in ODM males fed a HFD.Conclusion:When combined with other risk factors like HFD and aging, changes in glucose metabolism and hematopoiesis may contribute to the increased risk of obesity, type 2 diabetes, and hypertension observed in children of GDM mothers.

AB - Background:Children exposed to gestational diabetes mellitus (GDM) during pregnancy are at increased risk of obesity, diabetes, and hypertension. Our goal was to identify metabolic and hematopoietic alterations after intrauterine exposure to maternal hyperglycemia that may contribute to the pathogenesis of chronic morbidities.Methods:Streptozotocin treatment induced maternal hyperglycemia during the last third of gestation in rat dams. Offspring of control mothers (OCM) and diabetic mothers (ODM) were evaluated for weight, glucose tolerance, insulin tolerance, and hematopoiesis defects. The effects of aging were examined in normal and high-fat diet (HFD)-fed young (8-wk-old) and aged (11-mo-old) OCM and ODM rats.Results:Young adult ODM males on a normal diet, but not females, displayed improved glucose tolerance due to increased insulin levels. Aged ODM males and females gained more weight than OCM on a HFD and had worse glucose tolerance. Aged ODM males fed a HFD were also neutrophilic. Increases in bone marrow cellularity and myeloid progenitors preceded neutrophilia in ODM males fed a HFD.Conclusion:When combined with other risk factors like HFD and aging, changes in glucose metabolism and hematopoiesis may contribute to the increased risk of obesity, type 2 diabetes, and hypertension observed in children of GDM mothers.

UR - http://www.scopus.com/inward/record.url?scp=84927144952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927144952&partnerID=8YFLogxK

U2 - 10.1038/pr.2014.185

DO - 10.1038/pr.2014.185

M3 - Article

C2 - 25412163

AN - SCOPUS:84927144952

VL - 77

SP - 316

EP - 325

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 2

ER -