Fetal pH improvement after 24 h of severe, nonlethal hypoxia

Randall B. Wilkening, David W. Boyle, Giacomo Meschia

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The accumulation of hydrogen ions in fetal blood when fetal oxygenation is acutely decreased suggests metabolic instability. However, in 6 chronically prepared fetal sheep whose arterial O2 content and pO2 were abruptly reduced and maintained at about 1.7 mM and 12.6 Torr, respectively, we observed a significant decrease in fetal arterial lactate concentrations and an increase in pH to normal values after 24 h of continuous hypoxia compared with values observed after 5 h. This demonstrates that fetal pH measurements may not detect prolonged intrauterine hypoxia.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes


  • Blood flow
  • Fetus
  • Hypoxia
  • Lactate
  • pH

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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