FGF23 and the regulation of phosphorus metabolism

Research output: Chapter in Book/Report/Conference proceedingChapter


Disorders of phosphate (Pi) homeostasis, in concert with powerful in vitro and in vivo studies have shown that fibroblast growth factor 23 (FGF23) is central to the control of renal Pi and vitamin D homeostasis. Parathyroid hormone (PTH) is a central regulator of calcium balance, with hypocalcemia stimulating its secretion. In addition to its effects on calcium, PTH has been very well characterized as a key hormonal regulator of serum phosphate. In humans, dietary Pi supplementation increased FGF23 whereas Pi restriction and the addition of Pi binders suppressed serum FGF23, supporting that FGF23 plays a role in maintenance of Pi homeostasis. Heritable disorders of hyperphosphatemia and elevated 1,25(OH)2D, such as tumoral calcinosis (TC), are associated with reduced FGF23 activity. These collective findings have provided unique insight into the activity of FGF23 on renal Pi and vitamin D metabolism.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Number of pages7
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
StatePublished - Jan 1 2018


  • Fibroblast growth factor 23
  • Hyperphosphatemia
  • Parathyroid hormone
  • Phosphorus metabolism
  • Serum phosphate
  • Tumoral calcinosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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